Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist

Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) and a non-catechol agonist Compound 1 which explains...

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Autores principales:	Bingfa Sun, Dan Feng, Matthew Ling-Hon Chu, Inbar Fish, Silvia Lovera, Zara A. Sands, Sebastian Kelm, Anne Valade, Martyn Wood, Tom Ceska, Tong Sun Kobilka, Florence Lebon, Brian K. Kobilka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2dbb4259799647b08364c62567b2949b
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spelling	oai:doaj.org-article:2dbb4259799647b08364c62567b2949b2021-12-02T18:24:49ZCrystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist10.1038/s41467-021-23519-92041-1723https://doaj.org/article/2dbb4259799647b08364c62567b2949b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23519-9https://doaj.org/toc/2041-1723Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) and a non-catechol agonist Compound 1 which explains the selectivity of this scaffold for D1R over other aminergic receptors and the mechanism of activating D1R.Bingfa SunDan FengMatthew Ling-Hon ChuInbar FishSilvia LoveraZara A. SandsSebastian KelmAnne ValadeMartyn WoodTom CeskaTong Sun KobilkaFlorence LebonBrian K. KobilkaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bingfa Sun Dan Feng Matthew Ling-Hon Chu Inbar Fish Silvia Lovera Zara A. Sands Sebastian Kelm Anne Valade Martyn Wood Tom Ceska Tong Sun Kobilka Florence Lebon Brian K. Kobilka Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
description	Recently, a class of non-catechol Dopamine D1 receptor (D1R) selective agonists with novel scaffold and improved pharmacological properties were reported. Here, authors report the crystal structure of D1R in complex with stimulatory G protein (Gs) and a non-catechol agonist Compound 1 which explains the selectivity of this scaffold for D1R over other aminergic receptors and the mechanism of activating D1R.
format	article
author	Bingfa Sun Dan Feng Matthew Ling-Hon Chu Inbar Fish Silvia Lovera Zara A. Sands Sebastian Kelm Anne Valade Martyn Wood Tom Ceska Tong Sun Kobilka Florence Lebon Brian K. Kobilka
author_facet	Bingfa Sun Dan Feng Matthew Ling-Hon Chu Inbar Fish Silvia Lovera Zara A. Sands Sebastian Kelm Anne Valade Martyn Wood Tom Ceska Tong Sun Kobilka Florence Lebon Brian K. Kobilka
author_sort	Bingfa Sun
title	Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
title_short	Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
title_full	Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
title_fullStr	Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
title_full_unstemmed	Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
title_sort	crystal structure of dopamine d1 receptor in complex with g protein and a non-catechol agonist
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2dbb4259799647b08364c62567b2949b
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Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist

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