Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation

Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation

Aim. To study the features of the clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction (CHFprEF) in overweight and obese patients with concomitant atrial fibrillation (AF). Materials and methods. 248 overweight and obese patients with CHFprEF, ag...

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Autores principales: P. P. Bidzilya, V. H. Kadzharian, N. I. Kapshytar
Formato: article
Lenguaje:EN
RU
UK
Publicado: Zaporozhye State Medical University 2021
Materias:
clinical course
outcomes
chronic heart failure
preserved ejection fraction
obesity
atrial fibrillation
Medicine
R
Acceso en línea:https://doaj.org/article/2dbb8ad960c9480b87510b5fb8de772f
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spelling oai:doaj.org-article:2dbb8ad960c9480b87510b5fb8de772f2021-11-05T08:14:34ZClinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation10.14739/2310-1210.2021.6.2362472306-41452310-1210https://doaj.org/article/2dbb8ad960c9480b87510b5fb8de772f2021-11-01T00:00:00Zhttp://zmj.zsmu.edu.ua/article/view/236247/241656https://doaj.org/toc/2306-4145https://doaj.org/toc/2310-1210Aim. To study the features of the clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction (CHFprEF) in overweight and obese patients with concomitant atrial fibrillation (AF). Materials and methods. 248 overweight and obese patients with CHFprEF, aged 65.0 ± 11.0 years, 146 females (58.9 %) and 102 males (41.1 %) were examined. The first group consisted of 181 patients without concomitant AF, mean age 64.0 ± 11.0 years, 110 females (60.8 %) and 71 males (39.2 %). The second group included 67 patients with AF, mean age 67.9 ± 11.3 years, 36 females (53.7 %) and 31 males (46.3 %). Results. Comorbid AF was associated with a more severe course of CHFprEF by the rating scale of clinical state (0.9 points), Borg scale (1.7 points), a significant predominance of orthopnea (by 16.6 %), night cough (by 27.9 %), cardiac asthma (by 27.2 %), low exercise tolerance (by 14.3 %), weakness (by 23.7 %), palpitations (by 72.9 %), edema of the feet (by 40.6 %), rapid weight gain (by 32.6 %), jugular venous distention (by 21.4 %), pathological third heart sound (by 16.7 %), percussion extension of the cardiac borders (by 41.4 %) and dullness over the lungs (28.9 %), moist rales (24.3 %), second sound with a loud pulmonic component (by 33.9 %), tachypnea (by 25.9 %), hepatomegaly (by 32.0 %) and ascites (by 13.6 %), increased risk of cumulative endpoint (by 2.7 times), five-year mortality (by 3.4 times) and rehospitalization (by 3 times) (P ˂ 0.001). Conclusions. AF as the comorbidity in overweight and obese patients is associated with more severe clinical course of CHFprEF and worse five-year outcomes.P. P. BidzilyaV. H. KadzharianN. I. KapshytarZaporozhye State Medical Universityarticleclinical courseoutcomeschronic heart failurepreserved ejection fractionobesityatrial fibrillationMedicineRENRUUKZaporožskij Medicinskij Žurnal, Vol 23, Iss 6, Pp 778-783 (2021)
institution DOAJ
collection DOAJ
language EN
RU
UK
topic clinical course
outcomes
chronic heart failure
preserved ejection fraction
obesity
atrial fibrillation
Medicine
R
spellingShingle clinical course
outcomes
chronic heart failure
preserved ejection fraction
obesity
atrial fibrillation
Medicine
R
P. P. Bidzilya
V. H. Kadzharian
N. I. Kapshytar
Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation
description Aim. To study the features of the clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction (CHFprEF) in overweight and obese patients with concomitant atrial fibrillation (AF). Materials and methods. 248 overweight and obese patients with CHFprEF, aged 65.0 ± 11.0 years, 146 females (58.9 %) and 102 males (41.1 %) were examined. The first group consisted of 181 patients without concomitant AF, mean age 64.0 ± 11.0 years, 110 females (60.8 %) and 71 males (39.2 %). The second group included 67 patients with AF, mean age 67.9 ± 11.3 years, 36 females (53.7 %) and 31 males (46.3 %). Results. Comorbid AF was associated with a more severe course of CHFprEF by the rating scale of clinical state (0.9 points), Borg scale (1.7 points), a significant predominance of orthopnea (by 16.6 %), night cough (by 27.9 %), cardiac asthma (by 27.2 %), low exercise tolerance (by 14.3 %), weakness (by 23.7 %), palpitations (by 72.9 %), edema of the feet (by 40.6 %), rapid weight gain (by 32.6 %), jugular venous distention (by 21.4 %), pathological third heart sound (by 16.7 %), percussion extension of the cardiac borders (by 41.4 %) and dullness over the lungs (28.9 %), moist rales (24.3 %), second sound with a loud pulmonic component (by 33.9 %), tachypnea (by 25.9 %), hepatomegaly (by 32.0 %) and ascites (by 13.6 %), increased risk of cumulative endpoint (by 2.7 times), five-year mortality (by 3.4 times) and rehospitalization (by 3 times) (P ˂ 0.001). Conclusions. AF as the comorbidity in overweight and obese patients is associated with more severe clinical course of CHFprEF and worse five-year outcomes.
format article
author P. P. Bidzilya
V. H. Kadzharian
N. I. Kapshytar
author_facet P. P. Bidzilya
V. H. Kadzharian
N. I. Kapshytar
author_sort P. P. Bidzilya
title Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation
title_short Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation
title_full Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation
title_fullStr Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation
title_full_unstemmed Clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation
title_sort clinical course and outcomes of chronic heart failure with preserved left ventricular ejection fraction in concomitant overweight and obesity with comorbid atrial fibrillation
publisher Zaporozhye State Medical University
publishDate 2021
url https://doaj.org/article/2dbb8ad960c9480b87510b5fb8de772f
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AT vhkadzharian clinicalcourseandoutcomesofchronicheartfailurewithpreservedleftventricularejectionfractioninconcomitantoverweightandobesitywithcomorbidatrialfibrillation
AT nikapshytar clinicalcourseandoutcomesofchronicheartfailurewithpreservedleftventricularejectionfractioninconcomitantoverweightandobesitywithcomorbidatrialfibrillation
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