Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia

Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, whic...

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Autores principales:	Pierre Hirsch, Yanyan Zhang, Ruoping Tang, Virginie Joulin, Hélène Boutroux, Elodie Pronier, Hannah Moatti, Pascale Flandrin, Christophe Marzac, Dominique Bories, Fanny Fava, Hayat Mokrani, Aline Betems, Florence Lorre, Rémi Favier, Frédéric Féger, Mohamad Mohty, Luc Douay, Ollivier Legrand, Chrystèle Bilhou-Nabera, Fawzia Louache, François Delhommeau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2dbbe918315649bd816bccb6c1b9c78c
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spelling	oai:doaj.org-article:2dbbe918315649bd816bccb6c1b9c78c2021-12-02T17:32:37ZGenetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia10.1038/ncomms124752041-1723https://doaj.org/article/2dbbe918315649bd816bccb6c1b9c78c2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12475https://doaj.org/toc/2041-1723Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, which can be used to track evolution of the disease.Pierre HirschYanyan ZhangRuoping TangVirginie JoulinHélène BoutrouxElodie PronierHannah MoattiPascale FlandrinChristophe MarzacDominique BoriesFanny FavaHayat MokraniAline BetemsFlorence LorreRémi FavierFrédéric FégerMohamad MohtyLuc DouayOllivier LegrandChrystèle Bilhou-NaberaFawzia LouacheFrançois DelhommeauNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Hirsch Yanyan Zhang Ruoping Tang Virginie Joulin Hélène Boutroux Elodie Pronier Hannah Moatti Pascale Flandrin Christophe Marzac Dominique Bories Fanny Fava Hayat Mokrani Aline Betems Florence Lorre Rémi Favier Frédéric Féger Mohamad Mohty Luc Douay Ollivier Legrand Chrystèle Bilhou-Nabera Fawzia Louache François Delhommeau Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
description	Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, which can be used to track evolution of the disease.
format	article
author	Pierre Hirsch Yanyan Zhang Ruoping Tang Virginie Joulin Hélène Boutroux Elodie Pronier Hannah Moatti Pascale Flandrin Christophe Marzac Dominique Bories Fanny Fava Hayat Mokrani Aline Betems Florence Lorre Rémi Favier Frédéric Féger Mohamad Mohty Luc Douay Ollivier Legrand Chrystèle Bilhou-Nabera Fawzia Louache François Delhommeau
author_facet	Pierre Hirsch Yanyan Zhang Ruoping Tang Virginie Joulin Hélène Boutroux Elodie Pronier Hannah Moatti Pascale Flandrin Christophe Marzac Dominique Bories Fanny Fava Hayat Mokrani Aline Betems Florence Lorre Rémi Favier Frédéric Féger Mohamad Mohty Luc Douay Ollivier Legrand Chrystèle Bilhou-Nabera Fawzia Louache François Delhommeau
author_sort	Pierre Hirsch
title	Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
title_short	Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
title_full	Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
title_fullStr	Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
title_full_unstemmed	Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
title_sort	genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2dbbe918315649bd816bccb6c1b9c78c
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Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia

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