Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems

Understanding how platelets can sense and respond to hemodynamic forces in disturbed blood flow and complexed vasculature is crucial to the development of more effective and safer antithrombotic therapeutics. By incorporating diverse structural and functional designs, microfluidic technologies have...

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Autores principales:	Yingqi Zhang, Savindi De Zoysa Ramasundara, Renee Ellen Preketes-tardiani, Vivian Cheng, Hongxu Lu, Lining Arnold Ju
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	microfluidic platelet mechanobiology thrombosis hemodynamic endothelial cells Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/2dbc567ea3574743a5f6aab58ccc6792
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spelling	oai:doaj.org-article:2dbc567ea3574743a5f6aab58ccc67922021-12-01T00:19:34ZEmerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems2297-055X10.3389/fcvm.2021.766513https://doaj.org/article/2dbc567ea3574743a5f6aab58ccc67922021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.766513/fullhttps://doaj.org/toc/2297-055XUnderstanding how platelets can sense and respond to hemodynamic forces in disturbed blood flow and complexed vasculature is crucial to the development of more effective and safer antithrombotic therapeutics. By incorporating diverse structural and functional designs, microfluidic technologies have emerged to mimic microvascular anatomies and hemodynamic microenvironments, which open the floodgates for fascinating platelet mechanobiology investigations. The latest endothelialized microfluidics can even recapitulate the crosstalk between platelets and the circulatory system, including the vessel walls and plasma proteins such as von Willebrand factor. Hereby, we highlight these exciting microfluidic applications to platelet mechanobiology and platelet–circulatory system interplay as implicated in thrombosis. Last but not least, we discuss the need for microfluidic standardization and summarize the commercially available microfluidic platforms for researchers to obtain reproducible and consistent results in the field.Yingqi ZhangYingqi ZhangYingqi ZhangSavindi De Zoysa RamasundaraSavindi De Zoysa RamasundaraSavindi De Zoysa RamasundaraRenee Ellen Preketes-tardianiRenee Ellen Preketes-tardianiRenee Ellen Preketes-tardianiVivian ChengHongxu LuHongxu LuLining Arnold JuLining Arnold JuLining Arnold JuFrontiers Media S.A.articlemicrofluidicplateletmechanobiologythrombosishemodynamicendothelial cellsDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microfluidic platelet mechanobiology thrombosis hemodynamic endothelial cells Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	microfluidic platelet mechanobiology thrombosis hemodynamic endothelial cells Diseases of the circulatory (Cardiovascular) system RC666-701 Yingqi Zhang Yingqi Zhang Yingqi Zhang Savindi De Zoysa Ramasundara Savindi De Zoysa Ramasundara Savindi De Zoysa Ramasundara Renee Ellen Preketes-tardiani Renee Ellen Preketes-tardiani Renee Ellen Preketes-tardiani Vivian Cheng Hongxu Lu Hongxu Lu Lining Arnold Ju Lining Arnold Ju Lining Arnold Ju Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems
description	Understanding how platelets can sense and respond to hemodynamic forces in disturbed blood flow and complexed vasculature is crucial to the development of more effective and safer antithrombotic therapeutics. By incorporating diverse structural and functional designs, microfluidic technologies have emerged to mimic microvascular anatomies and hemodynamic microenvironments, which open the floodgates for fascinating platelet mechanobiology investigations. The latest endothelialized microfluidics can even recapitulate the crosstalk between platelets and the circulatory system, including the vessel walls and plasma proteins such as von Willebrand factor. Hereby, we highlight these exciting microfluidic applications to platelet mechanobiology and platelet–circulatory system interplay as implicated in thrombosis. Last but not least, we discuss the need for microfluidic standardization and summarize the commercially available microfluidic platforms for researchers to obtain reproducible and consistent results in the field.
format	article
author	Yingqi Zhang Yingqi Zhang Yingqi Zhang Savindi De Zoysa Ramasundara Savindi De Zoysa Ramasundara Savindi De Zoysa Ramasundara Renee Ellen Preketes-tardiani Renee Ellen Preketes-tardiani Renee Ellen Preketes-tardiani Vivian Cheng Hongxu Lu Hongxu Lu Lining Arnold Ju Lining Arnold Ju Lining Arnold Ju
author_facet	Yingqi Zhang Yingqi Zhang Yingqi Zhang Savindi De Zoysa Ramasundara Savindi De Zoysa Ramasundara Savindi De Zoysa Ramasundara Renee Ellen Preketes-tardiani Renee Ellen Preketes-tardiani Renee Ellen Preketes-tardiani Vivian Cheng Hongxu Lu Hongxu Lu Lining Arnold Ju Lining Arnold Ju Lining Arnold Ju
author_sort	Yingqi Zhang
title	Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems
title_short	Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems
title_full	Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems
title_fullStr	Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems
title_full_unstemmed	Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems
title_sort	emerging microfluidic approaches for platelet mechanobiology and interplay with circulatory systems
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2dbc567ea3574743a5f6aab58ccc6792
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Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems

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