Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation

The design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in the pharmaceutical industry. Its purpose is to modulate the physicochemical properties of active pharmaceutical ingredients (APIs), most of them already existing in the market, achieving imp...

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Autores principales:	Francisco Javier Acebedo-Martínez, Carolina Alarcón-Payer, Lucía Rodríguez-Domingo, Alicia Domínguez-Martín, Jaime Gómez-Morales, Duane Choquesillo-Lazarte
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/2dbd11e4465a4bdf88ead726879edd45
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spelling	oai:doaj.org-article:2dbd11e4465a4bdf88ead726879edd452021-11-25T17:18:27ZFurosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation10.3390/cryst111113392073-4352https://doaj.org/article/2dbd11e4465a4bdf88ead726879edd452021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4352/11/11/1339https://doaj.org/toc/2073-4352The design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in the pharmaceutical industry. Its purpose is to modulate the physicochemical properties of active pharmaceutical ingredients (APIs), most of them already existing in the market, achieving improved bioavailability properties, especially on oral administration drugs. In this work, our efforts are focused on the mechanochemical synthesis and thorough solid-state characterization of two drug–drug cocrystals involving furosemide and two different non-steroidal anti-inflammatory drugs (NSAIDs) commonly prescribed together: ethenzamide and piroxicam. Besides powder and single crystal X-ray diffraction, infrared spectroscopy and thermal analysis, stability, and solubility tests were performed on the new solid materials. The aim of this work was evaluating the physicochemical properties of such APIs in the new formulation, which revealed a solubility improvement regarding the NSAIDs but not in furosemide. Further studies need to be carried out to evaluate the drug–drug interaction in the novel multicomponent solids, looking for potential novel therapeutic alternatives.Francisco Javier Acebedo-MartínezCarolina Alarcón-PayerLucía Rodríguez-DomingoAlicia Domínguez-MartínJaime Gómez-MoralesDuane Choquesillo-LazarteMDPI AGarticledrug–drug cocrystalfurosemideethenzamidepiroxicammechanochemical synthesisCrystallographyQD901-999ENCrystals, Vol 11, Iss 1339, p 1339 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis Crystallography QD901-999
spellingShingle	drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis Crystallography QD901-999 Francisco Javier Acebedo-Martínez Carolina Alarcón-Payer Lucía Rodríguez-Domingo Alicia Domínguez-Martín Jaime Gómez-Morales Duane Choquesillo-Lazarte Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
description	The design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in the pharmaceutical industry. Its purpose is to modulate the physicochemical properties of active pharmaceutical ingredients (APIs), most of them already existing in the market, achieving improved bioavailability properties, especially on oral administration drugs. In this work, our efforts are focused on the mechanochemical synthesis and thorough solid-state characterization of two drug–drug cocrystals involving furosemide and two different non-steroidal anti-inflammatory drugs (NSAIDs) commonly prescribed together: ethenzamide and piroxicam. Besides powder and single crystal X-ray diffraction, infrared spectroscopy and thermal analysis, stability, and solubility tests were performed on the new solid materials. The aim of this work was evaluating the physicochemical properties of such APIs in the new formulation, which revealed a solubility improvement regarding the NSAIDs but not in furosemide. Further studies need to be carried out to evaluate the drug–drug interaction in the novel multicomponent solids, looking for potential novel therapeutic alternatives.
format	article
author	Francisco Javier Acebedo-Martínez Carolina Alarcón-Payer Lucía Rodríguez-Domingo Alicia Domínguez-Martín Jaime Gómez-Morales Duane Choquesillo-Lazarte
author_facet	Francisco Javier Acebedo-Martínez Carolina Alarcón-Payer Lucía Rodríguez-Domingo Alicia Domínguez-Martín Jaime Gómez-Morales Duane Choquesillo-Lazarte
author_sort	Francisco Javier Acebedo-Martínez
title	Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
title_short	Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
title_full	Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
title_fullStr	Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
title_full_unstemmed	Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
title_sort	furosemide/non-steroidal anti-inflammatory drug–drug pharmaceutical solids: novel opportunities in drug formulation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2dbd11e4465a4bdf88ead726879edd45
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Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation

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