PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION

Data of histological study of pathomorphological changes in liver of white mice with experimental plague are represented in the article. An important element in evaluation and prediction of the pathological process in the liver is the analysis of hepatocyte karyokinesis, the mitotic index calculatio...

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Autores principales:	V. I. Dubrovina, T. P. Starovoytova, S. A. Vityazeva, G. B. Mukhturgin, M. Y. Kotlov, S. V. Balakhonov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	yersinia pestis liver hepatocyte mitosis granuloma Science Q
Acceso en línea:	https://doaj.org/article/2dbea1d051b645de99e4422ea83939a4
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spelling	oai:doaj.org-article:2dbea1d051b645de99e4422ea83939a42021-11-23T06:14:37ZPATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION2541-94202587-959610.12737/article_59a614fbe83145.69615594https://doaj.org/article/2dbea1d051b645de99e4422ea83939a42017-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/622https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Data of histological study of pathomorphological changes in liver of white mice with experimental plague are represented in the article. An important element in evaluation and prediction of the pathological process in the liver is the analysis of hepatocyte karyokinesis, the mitotic index calculation, the counting number of atypical mitosis and the degree of organ regeneration ability. Dynamics of these liver changes at infection process in experimental animals caused by Yersinia pestis plasmid variants was investigated in this work. The variability of liver injuries was shown depending on plasmid-associated virulence of the infection agent. It was proved that the Y. pestis strain carrying three basic pYP (6 mDa), pYV (45 mDa), pYT (61 mDa) plasmids caused the most severe systemic disease with lethal outcome as a rule. Lack of species-specific plasmids and especially virulence and pathogenicity plasmids reduced the rate of infection process generalization and the ability of the pathogen to initiate pathological changes incompatible with the microorganism life. Therefore, all morphological liver changes in experimental plague infection are directly dependent on plasmid profile of the pathogen. The mechanism of toxicity included the damaging effect of the toxin to the cellular structures and failure of the metabolic processes in the organism. Acuity of intoxication and the development of pathological process can be estimated by exploring changes in liver morphology.V. I. DubrovinaT. P. StarovoytovaS. A. VityazevaG. B. MukhturginM. Y. KotlovS. V. BalakhonovScientific Сentre for Family Health and Human Reproduction Problemsarticleyersinia pestisliveryersinia pestishepatocytemitosisgranulomaScienceQRUActa Biomedica Scientifica, Vol 2, Iss 2, Pp 69-73 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	yersinia pestis liver yersinia pestis hepatocyte mitosis granuloma Science Q
spellingShingle	yersinia pestis liver yersinia pestis hepatocyte mitosis granuloma Science Q V. I. Dubrovina T. P. Starovoytova S. A. Vityazeva G. B. Mukhturgin M. Y. Kotlov S. V. Balakhonov PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION
description	Data of histological study of pathomorphological changes in liver of white mice with experimental plague are represented in the article. An important element in evaluation and prediction of the pathological process in the liver is the analysis of hepatocyte karyokinesis, the mitotic index calculation, the counting number of atypical mitosis and the degree of organ regeneration ability. Dynamics of these liver changes at infection process in experimental animals caused by Yersinia pestis plasmid variants was investigated in this work. The variability of liver injuries was shown depending on plasmid-associated virulence of the infection agent. It was proved that the Y. pestis strain carrying three basic pYP (6 mDa), pYV (45 mDa), pYT (61 mDa) plasmids caused the most severe systemic disease with lethal outcome as a rule. Lack of species-specific plasmids and especially virulence and pathogenicity plasmids reduced the rate of infection process generalization and the ability of the pathogen to initiate pathological changes incompatible with the microorganism life. Therefore, all morphological liver changes in experimental plague infection are directly dependent on plasmid profile of the pathogen. The mechanism of toxicity included the damaging effect of the toxin to the cellular structures and failure of the metabolic processes in the organism. Acuity of intoxication and the development of pathological process can be estimated by exploring changes in liver morphology.
format	article
author	V. I. Dubrovina T. P. Starovoytova S. A. Vityazeva G. B. Mukhturgin M. Y. Kotlov S. V. Balakhonov
author_facet	V. I. Dubrovina T. P. Starovoytova S. A. Vityazeva G. B. Mukhturgin M. Y. Kotlov S. V. Balakhonov
author_sort	V. I. Dubrovina
title	PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION
title_short	PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION
title_full	PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION
title_fullStr	PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION
title_full_unstemmed	PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION
title_sort	pathomorphological changes in liver of white mice at experimental plague infection caused by yersinia pestis of different plasmid composition
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/2dbea1d051b645de99e4422ea83939a4
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_version_	1718416997397561344

PATHOMORPHOLOGICAL CHANGES IN LIVER OF WHITE MICE AT EXPERIMENTAL PLAGUE INFECTION CAUSED BY YERSINIA PESTIS OF DIFFERENT PLASMID COMPOSITION

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