Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

The presence of the unnatural amino acid l-allo-enduracidine in the cyclic scaffold of teixobactin complicates its total synthesis. Here, the authors developed a convergent strategy for the scalable synthesis teixobactin and found two potent analogous.

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Autores principales:	Yu Zong, Fang Fang, Kirsten J. Meyer, Liguo Wang, Zhihao Ni, Hongying Gao, Kim Lewis, Jingren Zhang, Yu Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2dbf426f02bf45b4a8e84e24a494cbc7
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spelling	oai:doaj.org-article:2dbf426f02bf45b4a8e84e24a494cbc72021-12-02T16:57:23ZGram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics10.1038/s41467-019-11211-y2041-1723https://doaj.org/article/2dbf426f02bf45b4a8e84e24a494cbc72019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11211-yhttps://doaj.org/toc/2041-1723The presence of the unnatural amino acid l-allo-enduracidine in the cyclic scaffold of teixobactin complicates its total synthesis. Here, the authors developed a convergent strategy for the scalable synthesis teixobactin and found two potent analogous.Yu ZongFang FangKirsten J. MeyerLiguo WangZhihao NiHongying GaoKim LewisJingren ZhangYu RaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Zong Fang Fang Kirsten J. Meyer Liguo Wang Zhihao Ni Hongying Gao Kim Lewis Jingren Zhang Yu Rao Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
description	The presence of the unnatural amino acid l-allo-enduracidine in the cyclic scaffold of teixobactin complicates its total synthesis. Here, the authors developed a convergent strategy for the scalable synthesis teixobactin and found two potent analogous.
format	article
author	Yu Zong Fang Fang Kirsten J. Meyer Liguo Wang Zhihao Ni Hongying Gao Kim Lewis Jingren Zhang Yu Rao
author_facet	Yu Zong Fang Fang Kirsten J. Meyer Liguo Wang Zhihao Ni Hongying Gao Kim Lewis Jingren Zhang Yu Rao
author_sort	Yu Zong
title	Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
title_short	Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
title_full	Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
title_fullStr	Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
title_full_unstemmed	Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
title_sort	gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2dbf426f02bf45b4a8e84e24a494cbc7
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Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics

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