Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Background Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment. We investigated the effect of edaravone on the pial arteriolar diameter changes induced by...

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Auteurs principaux:	Tomohiro Michino, Kumiko Tanabe, Motoyasu Takenaka, Shigeru Akamatsu, Masayoshi Uchida, Mami Iida, Hiroki Iida
Format:	article
Langue:	EN
Publié:	Korean Society of Anesthesiologists 2021
Sujets:	cerebrovascular circulation edaravone endothelium free radical scavengers reperfusion injury vascular surgical procedures Anesthesiology RD78.3-87.3
Accès en ligne:	https://doaj.org/article/2dbf5a2dd00e454c982d8ed9c7001ac4
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spelling	oai:doaj.org-article:2dbf5a2dd00e454c982d8ed9c7001ac42021-11-30T23:47:49ZEdaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits2005-64192005-756310.4097/kja.21155https://doaj.org/article/2dbf5a2dd00e454c982d8ed9c7001ac42021-12-01T00:00:00Zhttp://ekja.org/upload/pdf/kja-21155.pdfhttps://doaj.org/toc/2005-6419https://doaj.org/toc/2005-7563Background Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment. We investigated the effect of edaravone on the pial arteriolar diameter changes induced by abdominal aortic surgery and the involvement of the endothelium in the changes. Methods The closed cranial window technique was used in rabbits to measure changes in pial arteriolar diameter after the unclamping of abdominal aortic cross-clamping with an intravenous free radical scavenger, edaravone (control group [n = 6], edaravone 10 μg/kg/ min [n = 6], 100 μg/kg/min [n = 6]). Pial vasodilatory responses to topical application of acetylcholine (ACh) into the cranial window were investigated before abdominal aortic cross-clamping and after unclamping with intravenous administration of edaravone (control group [n = 6], edaravone 100 μg/kg/min [n = 6]). Results Aortic unclamping-induced vasoconstriction was significantly attenuated by continuous infusion of edaravone at 100 μg/kg/min. Topical ACh after unclamping did not produce any changes in pial arteriolar responses in comparison to before aortic cross-clamping in the control or edaravone groups. The changes in the response to topical ACh after unclamping in the saline and edaravone groups did not differ significantly. Conclusions Free radicals during abdominal aortic surgery might have contracted cerebral blood vessels independently of endothelial function in rabbits. Suppression of free radicals attenuated the sustained pial arteriolar vasoconstriction after aortic unclamping. Thus, the free radical scavenger might have some brain protective effect that maintains CBF independently of endothelial function.Tomohiro MichinoKumiko TanabeMotoyasu TakenakaShigeru AkamatsuMasayoshi UchidaMami IidaHiroki IidaKorean Society of Anesthesiologistsarticlecerebrovascular circulationedaravoneendotheliumfree radical scavengersreperfusion injuryvascular surgical proceduresAnesthesiologyRD78.3-87.3ENKorean Journal of Anesthesiology, Vol 74, Iss 6, Pp 531-540 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebrovascular circulation edaravone endothelium free radical scavengers reperfusion injury vascular surgical procedures Anesthesiology RD78.3-87.3
spellingShingle	cerebrovascular circulation edaravone endothelium free radical scavengers reperfusion injury vascular surgical procedures Anesthesiology RD78.3-87.3 Tomohiro Michino Kumiko Tanabe Motoyasu Takenaka Shigeru Akamatsu Masayoshi Uchida Mami Iida Hiroki Iida Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
description	Background Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment. We investigated the effect of edaravone on the pial arteriolar diameter changes induced by abdominal aortic surgery and the involvement of the endothelium in the changes. Methods The closed cranial window technique was used in rabbits to measure changes in pial arteriolar diameter after the unclamping of abdominal aortic cross-clamping with an intravenous free radical scavenger, edaravone (control group [n = 6], edaravone 10 μg/kg/ min [n = 6], 100 μg/kg/min [n = 6]). Pial vasodilatory responses to topical application of acetylcholine (ACh) into the cranial window were investigated before abdominal aortic cross-clamping and after unclamping with intravenous administration of edaravone (control group [n = 6], edaravone 100 μg/kg/min [n = 6]). Results Aortic unclamping-induced vasoconstriction was significantly attenuated by continuous infusion of edaravone at 100 μg/kg/min. Topical ACh after unclamping did not produce any changes in pial arteriolar responses in comparison to before aortic cross-clamping in the control or edaravone groups. The changes in the response to topical ACh after unclamping in the saline and edaravone groups did not differ significantly. Conclusions Free radicals during abdominal aortic surgery might have contracted cerebral blood vessels independently of endothelial function in rabbits. Suppression of free radicals attenuated the sustained pial arteriolar vasoconstriction after aortic unclamping. Thus, the free radical scavenger might have some brain protective effect that maintains CBF independently of endothelial function.
format	article
author	Tomohiro Michino Kumiko Tanabe Motoyasu Takenaka Shigeru Akamatsu Masayoshi Uchida Mami Iida Hiroki Iida
author_facet	Tomohiro Michino Kumiko Tanabe Motoyasu Takenaka Shigeru Akamatsu Masayoshi Uchida Mami Iida Hiroki Iida
author_sort	Tomohiro Michino
title	Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
title_short	Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
title_full	Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
title_fullStr	Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
title_full_unstemmed	Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
title_sort	edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
publisher	Korean Society of Anesthesiologists
publishDate	2021
url	https://doaj.org/article/2dbf5a2dd00e454c982d8ed9c7001ac4
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Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

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