WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells

WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells

The role of cargo receptors in proinsulin export from the ER is unclear. Here, the authors identify the WFS1 protein, which is mutated in Wolfram syndrome and associated with diabetes, as an ER to Golgi cargo receptor required for normal insulin processing and secretion.

Guardado en:
Detalles Bibliográficos
Autores principales: Linlin Wang, Hongyang Liu, Xiaofei Zhang, Eli Song, You Wang, Tao Xu, Zonghong Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/2dbfff4106d24b84a1198b1c6c0b10e8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2dbfff4106d24b84a1198b1c6c0b10e8
record_format dspace
spelling oai:doaj.org-article:2dbfff4106d24b84a1198b1c6c0b10e82021-12-05T12:21:43ZWFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells10.1038/s41467-021-27344-y2041-1723https://doaj.org/article/2dbfff4106d24b84a1198b1c6c0b10e82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27344-yhttps://doaj.org/toc/2041-1723The role of cargo receptors in proinsulin export from the ER is unclear. Here, the authors identify the WFS1 protein, which is mutated in Wolfram syndrome and associated with diabetes, as an ER to Golgi cargo receptor required for normal insulin processing and secretion.Linlin WangHongyang LiuXiaofei ZhangEli SongYou WangTao XuZonghong LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Linlin Wang
Hongyang Liu
Xiaofei Zhang
Eli Song
You Wang
Tao Xu
Zonghong Li
WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
description The role of cargo receptors in proinsulin export from the ER is unclear. Here, the authors identify the WFS1 protein, which is mutated in Wolfram syndrome and associated with diabetes, as an ER to Golgi cargo receptor required for normal insulin processing and secretion.
format article
author Linlin Wang
Hongyang Liu
Xiaofei Zhang
Eli Song
You Wang
Tao Xu
Zonghong Li
author_facet Linlin Wang
Hongyang Liu
Xiaofei Zhang
Eli Song
You Wang
Tao Xu
Zonghong Li
author_sort Linlin Wang
title WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
title_short WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
title_full WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
title_fullStr WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
title_full_unstemmed WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
title_sort wfs1 functions in er export of vesicular cargo proteins in pancreatic β-cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2dbfff4106d24b84a1198b1c6c0b10e8
work_keys_str_mv AT linlinwang wfs1functionsinerexportofvesicularcargoproteinsinpancreaticbcells
AT hongyangliu wfs1functionsinerexportofvesicularcargoproteinsinpancreaticbcells
AT xiaofeizhang wfs1functionsinerexportofvesicularcargoproteinsinpancreaticbcells
AT elisong wfs1functionsinerexportofvesicularcargoproteinsinpancreaticbcells
AT youwang wfs1functionsinerexportofvesicularcargoproteinsinpancreaticbcells
AT taoxu wfs1functionsinerexportofvesicularcargoproteinsinpancreaticbcells
AT zonghongli wfs1functionsinerexportofvesicularcargoproteinsinpancreaticbcells
_version_ 1718372007290077184

Ejemplares similares