WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss

Abstract WHO grade I meningiomas occasionally show regrowth after radiosurgical treatment, which cannot be predicted by clinical features. There is increasing evidence that certain biomarkers are associated with regrowth of meningiomas. The aim of this retrospective study was to asses if these bioma...

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Autores principales:	Pim J. J. Damen, Vincent J. Bulthuis, Patrick E. J. Hanssens, Suan Te Lie, Ruth Fleischeuer, Veerle Melotte, Kim A. Wouters, Andrea Ruland, Jan Beckervordersandforth, Ernst Jan M. Speel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2dc5a0c13c81421a87bc2d6145914b79
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spelling	oai:doaj.org-article:2dc5a0c13c81421a87bc2d6145914b792021-12-02T18:50:59ZWHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss10.1038/s41598-021-95956-x2045-2322https://doaj.org/article/2dc5a0c13c81421a87bc2d6145914b792021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95956-xhttps://doaj.org/toc/2045-2322Abstract WHO grade I meningiomas occasionally show regrowth after radiosurgical treatment, which cannot be predicted by clinical features. There is increasing evidence that certain biomarkers are associated with regrowth of meningiomas. The aim of this retrospective study was to asses if these biomarkers could be of value to predict regrowth of WHO grade I meningiomas after additive radiosurgery. Forty-four patients with WHO grade I meningiomas who underwent additive radiosurgical treatment between 2002 and 2015 after Simpson IV resection were included in this study, of which 8 showed regrowth. Median follow-up time was 64 months (range 24–137 months). Tumors were analyzed for the proliferation marker Ki-67 by immunohistochemistry and for deletion of 1p36 by fluorescence in situ hybridization (FISH). Furthermore, genomic DNA was analyzed for promoter hypermethylation of the genes NDRG1–4, SFRP1, HOXA9 and MGMT. Comparison of meningiomas with and without regrowth after radiosurgery revealed that loss of 1p36 (p = 0.001) and hypermethylation of NDRG1 (p = 0.046) were correlated with regrowth free survival. Loss of 1p36 was the only parameter that was significantly associated with meningioma regrowth after multivariate analysis (p = 0.01). Assessment of 1p36 loss in tumor tissue prior to radiosurgery might be considered an indicator of prognosis/regrowth. However, this finding has to be validated in an independent larger set of tumors.Pim J. J. DamenVincent J. BulthuisPatrick E. J. HanssensSuan Te LieRuth FleischeuerVeerle MelotteKim A. WoutersAndrea RulandJan BeckervordersandforthErnst Jan M. SpeelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pim J. J. Damen Vincent J. Bulthuis Patrick E. J. Hanssens Suan Te Lie Ruth Fleischeuer Veerle Melotte Kim A. Wouters Andrea Ruland Jan Beckervordersandforth Ernst Jan M. Speel WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
description	Abstract WHO grade I meningiomas occasionally show regrowth after radiosurgical treatment, which cannot be predicted by clinical features. There is increasing evidence that certain biomarkers are associated with regrowth of meningiomas. The aim of this retrospective study was to asses if these biomarkers could be of value to predict regrowth of WHO grade I meningiomas after additive radiosurgery. Forty-four patients with WHO grade I meningiomas who underwent additive radiosurgical treatment between 2002 and 2015 after Simpson IV resection were included in this study, of which 8 showed regrowth. Median follow-up time was 64 months (range 24–137 months). Tumors were analyzed for the proliferation marker Ki-67 by immunohistochemistry and for deletion of 1p36 by fluorescence in situ hybridization (FISH). Furthermore, genomic DNA was analyzed for promoter hypermethylation of the genes NDRG1–4, SFRP1, HOXA9 and MGMT. Comparison of meningiomas with and without regrowth after radiosurgery revealed that loss of 1p36 (p = 0.001) and hypermethylation of NDRG1 (p = 0.046) were correlated with regrowth free survival. Loss of 1p36 was the only parameter that was significantly associated with meningioma regrowth after multivariate analysis (p = 0.01). Assessment of 1p36 loss in tumor tissue prior to radiosurgery might be considered an indicator of prognosis/regrowth. However, this finding has to be validated in an independent larger set of tumors.
format	article
author	Pim J. J. Damen Vincent J. Bulthuis Patrick E. J. Hanssens Suan Te Lie Ruth Fleischeuer Veerle Melotte Kim A. Wouters Andrea Ruland Jan Beckervordersandforth Ernst Jan M. Speel
author_facet	Pim J. J. Damen Vincent J. Bulthuis Patrick E. J. Hanssens Suan Te Lie Ruth Fleischeuer Veerle Melotte Kim A. Wouters Andrea Ruland Jan Beckervordersandforth Ernst Jan M. Speel
author_sort	Pim J. J. Damen
title	WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
title_short	WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
title_full	WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
title_fullStr	WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
title_full_unstemmed	WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
title_sort	who grade i meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2dc5a0c13c81421a87bc2d6145914b79
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WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss

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