Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study

Abstract The coexistence of inflammatory bowel disease (IBD) and bullous pemphigoid (BP) has been reported. No large-scale study to date has explored the relationship between these diseases. This population-based case-control study examined the association between IBD and BP by using a nationwide da...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi-Ju Chen, Chao-Kuei Juan, Yun-Ting Chang, Chun-Ying Wu, Hsiu J. Ho, Hsiao-Ching Tseng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2dca92e9c726409e8d0c24cdc6978f2c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2dca92e9c726409e8d0c24cdc6978f2c
record_format	dspace
spelling	oai:doaj.org-article:2dca92e9c726409e8d0c24cdc6978f2c2021-12-02T16:06:39ZAssociation between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study10.1038/s41598-020-69475-02045-2322https://doaj.org/article/2dca92e9c726409e8d0c24cdc6978f2c2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69475-0https://doaj.org/toc/2045-2322Abstract The coexistence of inflammatory bowel disease (IBD) and bullous pemphigoid (BP) has been reported. No large-scale study to date has explored the relationship between these diseases. This population-based case-control study examined the association between IBD and BP by using a nationwide database. A total of 5,263 BP patients and 21,052 age- and gender-, hospital visit number-matched controls were identified in the National Health Insurance Research Database of Taiwan (1997–2013). Demographic characteristics and comorbidities including IBD were compared. Logistic regression was conducted to examine the predicting factors for BP. The mean age at diagnosis was 74.88 years and 54.3% of subjects were male. BP patients tended to have more cardiovascular risk factors, autoimmune and neurologic comorbidities, and hematologic cancers than matched controls. There were 20 cases of IBD (0.38%), mostly ulcerative colitis (N = 17, 0.32%) among BP patients, compared to 33 IBD cases (0.16%) among controls (p < 0.001). Ulcerative colitis was found to be significantly associated with BP [adjusted odds ratio (OR) 3.60, 95% confidence interval (CI) 1.91–6.77, p < 0.001] on multivariate analysis. Treatment for IBD was not associated with BP development. Information about diet, lifestyle, alcohol consumption, and smoking habit was not available. We concluded that UC is independently associated with BP.Yi-Ju ChenChao-Kuei JuanYun-Ting ChangChun-Ying WuHsiu J. HoHsiao-Ching TsengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Ju Chen Chao-Kuei Juan Yun-Ting Chang Chun-Ying Wu Hsiu J. Ho Hsiao-Ching Tseng Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
description	Abstract The coexistence of inflammatory bowel disease (IBD) and bullous pemphigoid (BP) has been reported. No large-scale study to date has explored the relationship between these diseases. This population-based case-control study examined the association between IBD and BP by using a nationwide database. A total of 5,263 BP patients and 21,052 age- and gender-, hospital visit number-matched controls were identified in the National Health Insurance Research Database of Taiwan (1997–2013). Demographic characteristics and comorbidities including IBD were compared. Logistic regression was conducted to examine the predicting factors for BP. The mean age at diagnosis was 74.88 years and 54.3% of subjects were male. BP patients tended to have more cardiovascular risk factors, autoimmune and neurologic comorbidities, and hematologic cancers than matched controls. There were 20 cases of IBD (0.38%), mostly ulcerative colitis (N = 17, 0.32%) among BP patients, compared to 33 IBD cases (0.16%) among controls (p < 0.001). Ulcerative colitis was found to be significantly associated with BP [adjusted odds ratio (OR) 3.60, 95% confidence interval (CI) 1.91–6.77, p < 0.001] on multivariate analysis. Treatment for IBD was not associated with BP development. Information about diet, lifestyle, alcohol consumption, and smoking habit was not available. We concluded that UC is independently associated with BP.
format	article
author	Yi-Ju Chen Chao-Kuei Juan Yun-Ting Chang Chun-Ying Wu Hsiu J. Ho Hsiao-Ching Tseng
author_facet	Yi-Ju Chen Chao-Kuei Juan Yun-Ting Chang Chun-Ying Wu Hsiu J. Ho Hsiao-Ching Tseng
author_sort	Yi-Ju Chen
title	Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
title_short	Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
title_full	Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
title_fullStr	Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
title_full_unstemmed	Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
title_sort	association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2dca92e9c726409e8d0c24cdc6978f2c
work_keys_str_mv	AT yijuchen associationbetweeninflammatoryboweldiseaseandbullouspemphigoidapopulationbasedcasecontrolstudy AT chaokueijuan associationbetweeninflammatoryboweldiseaseandbullouspemphigoidapopulationbasedcasecontrolstudy AT yuntingchang associationbetweeninflammatoryboweldiseaseandbullouspemphigoidapopulationbasedcasecontrolstudy AT chunyingwu associationbetweeninflammatoryboweldiseaseandbullouspemphigoidapopulationbasedcasecontrolstudy AT hsiujho associationbetweeninflammatoryboweldiseaseandbullouspemphigoidapopulationbasedcasecontrolstudy AT hsiaochingtseng associationbetweeninflammatoryboweldiseaseandbullouspemphigoidapopulationbasedcasecontrolstudy
_version_	1718384893726031872

Association between inflammatory bowel disease and bullous pemphigoid: a population-based case–control study

Ejemplares similares