Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

Little is known about mechanisms that regulate the involvement of cortical engram cells in remote memory. Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength.

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Autores principales:	Mariana R. Matos, Esther Visser, Ioannis Kramvis, Rolinka J. van der Loo, Titia Gebuis, Robbert Zalm, Priyanka Rao-Ruiz, Huibert D. Mansvelder, August B. Smit, Michel C. van den Oever
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2dcc06a021f6409fbd0f338e392bb063
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spelling	oai:doaj.org-article:2dcc06a021f6409fbd0f338e392bb0632021-12-02T16:57:50ZMemory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory10.1038/s41467-019-10266-12041-1723https://doaj.org/article/2dcc06a021f6409fbd0f338e392bb0632019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10266-1https://doaj.org/toc/2041-1723Little is known about mechanisms that regulate the involvement of cortical engram cells in remote memory. Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength.Mariana R. MatosEsther VisserIoannis KramvisRolinka J. van der LooTitia GebuisRobbert ZalmPriyanka Rao-RuizHuibert D. MansvelderAugust B. SmitMichel C. van den OeverNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariana R. Matos Esther Visser Ioannis Kramvis Rolinka J. van der Loo Titia Gebuis Robbert Zalm Priyanka Rao-Ruiz Huibert D. Mansvelder August B. Smit Michel C. van den Oever Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
description	Little is known about mechanisms that regulate the involvement of cortical engram cells in remote memory. Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength.
format	article
author	Mariana R. Matos Esther Visser Ioannis Kramvis Rolinka J. van der Loo Titia Gebuis Robbert Zalm Priyanka Rao-Ruiz Huibert D. Mansvelder August B. Smit Michel C. van den Oever
author_facet	Mariana R. Matos Esther Visser Ioannis Kramvis Rolinka J. van der Loo Titia Gebuis Robbert Zalm Priyanka Rao-Ruiz Huibert D. Mansvelder August B. Smit Michel C. van den Oever
author_sort	Mariana R. Matos
title	Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
title_short	Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
title_full	Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
title_fullStr	Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
title_full_unstemmed	Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
title_sort	memory strength gates the involvement of a creb-dependent cortical fear engram in remote memory
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2dcc06a021f6409fbd0f338e392bb063
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Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory

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