COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS

Objective: To evaluate the ulceroprotective effects of Verapamil on aspirin-induced gastropathy in rabbits. Study Design: Laboratory based, quasi-experimental study. Place and Duration of Study: The study was conducted at the department of Pharmacology and Therapeutics in collaboration with Cl...

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Autores principales:	Muhammad Wasiullah Khan, Junaid Aslam, Ayesha Ellahi, Salma Bakhtiar
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	aspirin gastropathy ulceroprotective Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2dd5e56e42da44f99ae3e634d79cd127
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spelling	oai:doaj.org-article:2dd5e56e42da44f99ae3e634d79cd1272021-11-10T02:44:39ZCOMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS0030-96482411-8842https://doaj.org/article/2dd5e56e42da44f99ae3e634d79cd1272019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3416/2391https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the ulceroprotective effects of Verapamil on aspirin-induced gastropathy in rabbits. Study Design: Laboratory based, quasi-experimental study. Place and Duration of Study: The study was conducted at the department of Pharmacology and Therapeutics in collaboration with Clinico-Pathologic Laboratory, Army Medical College, Rawalpindi, from Apr to Jun 2016. Methodology: Eighteen rabbits were split into three groups, each consisting of six rabbits. Weight of rabbits was measured and dose was calculated accordingly. The first group was given single ulcer producing dose of aspirin 150mg/ kg body weight orally, after an overnight fast. The protective group was administered oral Verapamil 08mg/kg of body weight. Rabbits were sacrificed 01 hour after ulcerogenic dose of aspirin. Stomachs were recovered for ulcer index, pH and were referred for histopathology. Statistical analysis was carried out by using Microsoft Office Excel 2013 and SPSS version 22. One-way ANOVA, followed by ‘Post Hoc Tukey’ test was used for biochemical parameters. Results: Significant gastropathy was seen in toxic groups, with substantial elevation in ulcer index (p=0.001) and distinctly low pH (p=0.001). Ulcer protection was moderate with verapamil groups (percentage protection calculated for Verapamil was 15.18%). Conclusion: The ulcerogenic activity of Ca2+ influx (connected to peptic acid and gastrin secretion) was found to be ameliorated by antagonistic action of verapamil.Muhammad Wasiullah KhanJunaid AslamAyesha EllahiSalma BakhtiarArmy Medical College RawalpindiarticleaspiringastropathyulceroprotectiveMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 1070-1076 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	aspirin gastropathy ulceroprotective Medicine R Medicine (General) R5-920
spellingShingle	aspirin gastropathy ulceroprotective Medicine R Medicine (General) R5-920 Muhammad Wasiullah Khan Junaid Aslam Ayesha Ellahi Salma Bakhtiar COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS
description	Objective: To evaluate the ulceroprotective effects of Verapamil on aspirin-induced gastropathy in rabbits. Study Design: Laboratory based, quasi-experimental study. Place and Duration of Study: The study was conducted at the department of Pharmacology and Therapeutics in collaboration with Clinico-Pathologic Laboratory, Army Medical College, Rawalpindi, from Apr to Jun 2016. Methodology: Eighteen rabbits were split into three groups, each consisting of six rabbits. Weight of rabbits was measured and dose was calculated accordingly. The first group was given single ulcer producing dose of aspirin 150mg/ kg body weight orally, after an overnight fast. The protective group was administered oral Verapamil 08mg/kg of body weight. Rabbits were sacrificed 01 hour after ulcerogenic dose of aspirin. Stomachs were recovered for ulcer index, pH and were referred for histopathology. Statistical analysis was carried out by using Microsoft Office Excel 2013 and SPSS version 22. One-way ANOVA, followed by ‘Post Hoc Tukey’ test was used for biochemical parameters. Results: Significant gastropathy was seen in toxic groups, with substantial elevation in ulcer index (p=0.001) and distinctly low pH (p=0.001). Ulcer protection was moderate with verapamil groups (percentage protection calculated for Verapamil was 15.18%). Conclusion: The ulcerogenic activity of Ca2+ influx (connected to peptic acid and gastrin secretion) was found to be ameliorated by antagonistic action of verapamil.
format	article
author	Muhammad Wasiullah Khan Junaid Aslam Ayesha Ellahi Salma Bakhtiar
author_facet	Muhammad Wasiullah Khan Junaid Aslam Ayesha Ellahi Salma Bakhtiar
author_sort	Muhammad Wasiullah Khan
title	COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS
title_short	COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS
title_full	COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS
title_fullStr	COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS
title_full_unstemmed	COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS
title_sort	comparing the ulceroprotective effects of verapamil, ranitidine combination with omeprazoleon aspirin induced gastropathy in rabbits
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/2dd5e56e42da44f99ae3e634d79cd127
work_keys_str_mv	AT muhammadwasiullahkhan comparingtheulceroprotectiveeffectsofverapamilranitidinecombinationwithomeprazoleonaspirininducedgastropathyinrabbits AT junaidaslam comparingtheulceroprotectiveeffectsofverapamilranitidinecombinationwithomeprazoleonaspirininducedgastropathyinrabbits AT ayeshaellahi comparingtheulceroprotectiveeffectsofverapamilranitidinecombinationwithomeprazoleonaspirininducedgastropathyinrabbits AT salmabakhtiar comparingtheulceroprotectiveeffectsofverapamilranitidinecombinationwithomeprazoleonaspirininducedgastropathyinrabbits
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COMPARING THE ULCEROPROTECTIVE EFFECTS OF VERAPAMIL, RANITIDINE COMBINATION WITH OMEPRAZOLEON ASPIRIN INDUCED GASTROPATHY IN RABBITS

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