ATR regulates neuronal activity by modulating presynaptic firing

ATR regulates neuronal activity by modulating presynaptic firing

Ataxia Telangiectasia and Rad3-related (ATR) is a key regulator of replication stress response; yet, mutations within the ATR gene cause human ATR-Seckel Syndrome associated with microcephaly and intellectual disability. Here, the authors show neuron-specific ATR deletion increases intrinsic neurona...

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Autores principales: Murat Kirtay, Josefine Sell, Christian Marx, Holger Haselmann, Mihai Ceanga, Zhong-Wei Zhou, Vahid Rahmati, Joanna Kirkpatrick, Katrin Buder, Paulius Grigaravicius, Alessandro Ori, Christian Geis, Zhao-Qi Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2dd9c267ac854fe5bdc2ba175941b03b
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spelling oai:doaj.org-article:2dd9c267ac854fe5bdc2ba175941b03b2021-12-02T18:18:35ZATR regulates neuronal activity by modulating presynaptic firing10.1038/s41467-021-24217-22041-1723https://doaj.org/article/2dd9c267ac854fe5bdc2ba175941b03b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24217-2https://doaj.org/toc/2041-1723Ataxia Telangiectasia and Rad3-related (ATR) is a key regulator of replication stress response; yet, mutations within the ATR gene cause human ATR-Seckel Syndrome associated with microcephaly and intellectual disability. Here, the authors show neuron-specific ATR deletion increases intrinsic neuronal and epileptiform activity, revealing a function of ATR beyond its role in DNA damage response.Murat KirtayJosefine SellChristian MarxHolger HaselmannMihai CeangaZhong-Wei ZhouVahid RahmatiJoanna KirkpatrickKatrin BuderPaulius GrigaraviciusAlessandro OriChristian GeisZhao-Qi WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Murat Kirtay
Josefine Sell
Christian Marx
Holger Haselmann
Mihai Ceanga
Zhong-Wei Zhou
Vahid Rahmati
Joanna Kirkpatrick
Katrin Buder
Paulius Grigaravicius
Alessandro Ori
Christian Geis
Zhao-Qi Wang
ATR regulates neuronal activity by modulating presynaptic firing
description Ataxia Telangiectasia and Rad3-related (ATR) is a key regulator of replication stress response; yet, mutations within the ATR gene cause human ATR-Seckel Syndrome associated with microcephaly and intellectual disability. Here, the authors show neuron-specific ATR deletion increases intrinsic neuronal and epileptiform activity, revealing a function of ATR beyond its role in DNA damage response.
format article
author Murat Kirtay
Josefine Sell
Christian Marx
Holger Haselmann
Mihai Ceanga
Zhong-Wei Zhou
Vahid Rahmati
Joanna Kirkpatrick
Katrin Buder
Paulius Grigaravicius
Alessandro Ori
Christian Geis
Zhao-Qi Wang
author_facet Murat Kirtay
Josefine Sell
Christian Marx
Holger Haselmann
Mihai Ceanga
Zhong-Wei Zhou
Vahid Rahmati
Joanna Kirkpatrick
Katrin Buder
Paulius Grigaravicius
Alessandro Ori
Christian Geis
Zhao-Qi Wang
author_sort Murat Kirtay
title ATR regulates neuronal activity by modulating presynaptic firing
title_short ATR regulates neuronal activity by modulating presynaptic firing
title_full ATR regulates neuronal activity by modulating presynaptic firing
title_fullStr ATR regulates neuronal activity by modulating presynaptic firing
title_full_unstemmed ATR regulates neuronal activity by modulating presynaptic firing
title_sort atr regulates neuronal activity by modulating presynaptic firing
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2dd9c267ac854fe5bdc2ba175941b03b
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AT josefinesell atrregulatesneuronalactivitybymodulatingpresynapticfiring
AT christianmarx atrregulatesneuronalactivitybymodulatingpresynapticfiring
AT holgerhaselmann atrregulatesneuronalactivitybymodulatingpresynapticfiring
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