Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro

Using an in vitro culture system, Pezet et al. studied the influence of oxygen on the mitochondrial DNA (mtDNA) in primordial germ cell-like cells (PGCLCs) in vitro. Low oxygen levels resembling in vivo reduced the cell mtDNA content causing a genetic bottleneck and the segregation of different mtDN...

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Autores principales:	Mikael G. Pezet, Aurora Gomez-Duran, Florian Klimm, Juvid Aryaman, Stephen Burr, Wei Wei, Mitinori Saitou, Julien Prudent, Patrick F. Chinnery
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2ddd821695224939802015f7ff5f8b03
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spelling	oai:doaj.org-article:2ddd821695224939802015f7ff5f8b032021-12-02T16:50:31ZOxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro10.1038/s42003-021-02069-22399-3642https://doaj.org/article/2ddd821695224939802015f7ff5f8b032021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02069-2https://doaj.org/toc/2399-3642Using an in vitro culture system, Pezet et al. studied the influence of oxygen on the mitochondrial DNA (mtDNA) in primordial germ cell-like cells (PGCLCs) in vitro. Low oxygen levels resembling in vivo reduced the cell mtDNA content causing a genetic bottleneck and the segregation of different mtDNA genotypes.Mikael G. PezetAurora Gomez-DuranFlorian KlimmJuvid AryamanStephen BurrWei WeiMitinori SaitouJulien PrudentPatrick F. ChinneryNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mikael G. Pezet Aurora Gomez-Duran Florian Klimm Juvid Aryaman Stephen Burr Wei Wei Mitinori Saitou Julien Prudent Patrick F. Chinnery Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
description	Using an in vitro culture system, Pezet et al. studied the influence of oxygen on the mitochondrial DNA (mtDNA) in primordial germ cell-like cells (PGCLCs) in vitro. Low oxygen levels resembling in vivo reduced the cell mtDNA content causing a genetic bottleneck and the segregation of different mtDNA genotypes.
format	article
author	Mikael G. Pezet Aurora Gomez-Duran Florian Klimm Juvid Aryaman Stephen Burr Wei Wei Mitinori Saitou Julien Prudent Patrick F. Chinnery
author_facet	Mikael G. Pezet Aurora Gomez-Duran Florian Klimm Juvid Aryaman Stephen Burr Wei Wei Mitinori Saitou Julien Prudent Patrick F. Chinnery
author_sort	Mikael G. Pezet
title	Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
title_short	Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
title_full	Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
title_fullStr	Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
title_full_unstemmed	Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
title_sort	oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtdna variant in vitro
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ddd821695224939802015f7ff5f8b03
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Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro

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