Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation

Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-tolerance without clear adverse effects or the need for c...

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Autores principales:	Zhanzhuo Li, Agnieszka Czechowicz, Amelia Scheck, Derrick J. Rossi, Philip M. Murphy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2dddc27bdce0404992038db99358a2da
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spelling	oai:doaj.org-article:2dddc27bdce0404992038db99358a2da2021-12-02T16:50:56ZHematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation10.1038/s41467-018-08202-w2041-1723https://doaj.org/article/2dddc27bdce0404992038db99358a2da2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08202-whttps://doaj.org/toc/2041-1723Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-tolerance without clear adverse effects or the need for chronic immune suppression.Zhanzhuo LiAgnieszka CzechowiczAmelia ScheckDerrick J. RossiPhilip M. MurphyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhanzhuo Li Agnieszka Czechowicz Amelia Scheck Derrick J. Rossi Philip M. Murphy Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation
description	Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-tolerance without clear adverse effects or the need for chronic immune suppression.
format	article
author	Zhanzhuo Li Agnieszka Czechowicz Amelia Scheck Derrick J. Rossi Philip M. Murphy
author_facet	Zhanzhuo Li Agnieszka Czechowicz Amelia Scheck Derrick J. Rossi Philip M. Murphy
author_sort	Zhanzhuo Li
title	Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation
title_short	Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation
title_full	Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation
title_fullStr	Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation
title_full_unstemmed	Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation
title_sort	hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic cd117 antibody-drug-conjugate conditioning in mhc-mismatched allotransplantation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2dddc27bdce0404992038db99358a2da
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Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation

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