VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis
Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism. Chen et al. show that this process is essential in angiogenesis by demonstrating that the endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF.
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Nature Portfolio
2017
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oai:doaj.org-article:2dded3a4afa9422184dbcadb087614ec2021-12-02T14:42:07ZVEGF amplifies transcription through ETS1 acetylation to enable angiogenesis10.1038/s41467-017-00405-x2041-1723https://doaj.org/article/2dded3a4afa9422184dbcadb087614ec2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00405-xhttps://doaj.org/toc/2041-1723Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism. Chen et al. show that this process is essential in angiogenesis by demonstrating that the endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF.Jiahuan ChenYi FuDaniel S. DayYe SunShiyan WangXiaodong LiangFei GuFang ZhangSean M. StevensPingzhu ZhouKai LiYan ZhangRuei-zeng LinLois E. H. SmithJin ZhangKun SunJuan M. Melero-MartinZeguang HanPeter J. ParkBing ZhangWilliam T. PuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jiahuan Chen Yi Fu Daniel S. Day Ye Sun Shiyan Wang Xiaodong Liang Fei Gu Fang Zhang Sean M. Stevens Pingzhu Zhou Kai Li Yan Zhang Ruei-zeng Lin Lois E. H. Smith Jin Zhang Kun Sun Juan M. Melero-Martin Zeguang Han Peter J. Park Bing Zhang William T. Pu VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis |
| description |
Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism. Chen et al. show that this process is essential in angiogenesis by demonstrating that the endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF. |
| format |
article |
| author |
Jiahuan Chen Yi Fu Daniel S. Day Ye Sun Shiyan Wang Xiaodong Liang Fei Gu Fang Zhang Sean M. Stevens Pingzhu Zhou Kai Li Yan Zhang Ruei-zeng Lin Lois E. H. Smith Jin Zhang Kun Sun Juan M. Melero-Martin Zeguang Han Peter J. Park Bing Zhang William T. Pu |
| author_facet |
Jiahuan Chen Yi Fu Daniel S. Day Ye Sun Shiyan Wang Xiaodong Liang Fei Gu Fang Zhang Sean M. Stevens Pingzhu Zhou Kai Li Yan Zhang Ruei-zeng Lin Lois E. H. Smith Jin Zhang Kun Sun Juan M. Melero-Martin Zeguang Han Peter J. Park Bing Zhang William T. Pu |
| author_sort |
Jiahuan Chen |
| title |
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis |
| title_short |
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis |
| title_full |
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis |
| title_fullStr |
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis |
| title_full_unstemmed |
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis |
| title_sort |
vegf amplifies transcription through ets1 acetylation to enable angiogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/2dded3a4afa9422184dbcadb087614ec |
| work_keys_str_mv |
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1718389800438857728 |