VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis

Promoter proximal RNAPII pausing is a rate-limiting transcriptional mechanism. Chen et al. show that this process is essential in angiogenesis by demonstrating that the endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF.

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Auteurs principaux: Jiahuan Chen, Yi Fu, Daniel S. Day, Ye Sun, Shiyan Wang, Xiaodong Liang, Fei Gu, Fang Zhang, Sean M. Stevens, Pingzhu Zhou, Kai Li, Yan Zhang, Ruei-zeng Lin, Lois E. H. Smith, Jin Zhang, Kun Sun, Juan M. Melero-Martin, Zeguang Han, Peter J. Park, Bing Zhang, William T. Pu
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
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Accès en ligne:https://doaj.org/article/2dded3a4afa9422184dbcadb087614ec
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Internet

https://doaj.org/article/2dded3a4afa9422184dbcadb087614ec

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