Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid

Abstract Serious intraocular toxicity cases have been reported worldwide after the use of different perfluorocarbon liquids. The current study reports for the first-time the clinical pictures of cases of acute intraocular toxicity caused by MEROCTANE, a perfluoro-octane commercialized by a Turkish c...

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Autores principales:	Rosa M. Coco-Martin, Cristina Andrés-Iglesias, Girish K. Srivastava, Javier Lagos-Rodriguez, Miguel Ruiz-Tevah, Mario R. Díaz-Cárdenas, Ivan Fernandez-Bueno, Juan García-Serna, María T. García-Gutierrez, Alfredo García-Layana, J. Carlos Pastor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ddf4756e74c45e995f2f7ace156f680
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spelling	oai:doaj.org-article:2ddf4756e74c45e995f2f7ace156f6802021-12-02T14:12:41ZIntraocular toxicity caused by MEROCTANE perfluorocarbon liquid10.1038/s41598-020-79561-y2045-2322https://doaj.org/article/2ddf4756e74c45e995f2f7ace156f6802021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79561-yhttps://doaj.org/toc/2045-2322Abstract Serious intraocular toxicity cases have been reported worldwide after the use of different perfluorocarbon liquids. The current study reports for the first-time the clinical pictures of cases of acute intraocular toxicity caused by MEROCTANE, a perfluoro-octane commercialized by a Turkish company and distributed in many countries. A series of 18 cases from Chile and Spain was retrospectively analysed. To evaluate the impurity profile, a suspicious MEROCTANE sample (lot OCT.01.2013) was analysed by gas chromatography mass spectrometry and compared with a non-suspicious sample of the same commercial perfluoro-octane (lot OCT 722011). Cytotoxicity was tested following a direct-contact method, taking into consideration the high volatility and hydrophobicity of perfluoro-octane and following the ISO 10993 guideline. Cytotoxicity test showed clear cytotoxic effects of the analysed batch (less than 9% of cell viability). Moreover, chemical analysis demonstrated the presence of many contaminants, some highly toxic (acids and alcohols). Perfluorocarbon liquids are useful tools for intraocular surgery but companies and Agencies of Medical Devices must implement measures that guarantee the safety of these products based on both chemical and cytotoxicity analysis for every batch. Medical staff should be encouraged to report any suspected case to their respective National Agencies.Rosa M. Coco-MartinCristina Andrés-IglesiasGirish K. SrivastavaJavier Lagos-RodriguezMiguel Ruiz-TevahMario R. Díaz-CárdenasIvan Fernandez-BuenoJuan García-SernaMaría T. García-GutierrezAlfredo García-LayanaJ. Carlos PastorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosa M. Coco-Martin Cristina Andrés-Iglesias Girish K. Srivastava Javier Lagos-Rodriguez Miguel Ruiz-Tevah Mario R. Díaz-Cárdenas Ivan Fernandez-Bueno Juan García-Serna María T. García-Gutierrez Alfredo García-Layana J. Carlos Pastor Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid
description	Abstract Serious intraocular toxicity cases have been reported worldwide after the use of different perfluorocarbon liquids. The current study reports for the first-time the clinical pictures of cases of acute intraocular toxicity caused by MEROCTANE, a perfluoro-octane commercialized by a Turkish company and distributed in many countries. A series of 18 cases from Chile and Spain was retrospectively analysed. To evaluate the impurity profile, a suspicious MEROCTANE sample (lot OCT.01.2013) was analysed by gas chromatography mass spectrometry and compared with a non-suspicious sample of the same commercial perfluoro-octane (lot OCT 722011). Cytotoxicity was tested following a direct-contact method, taking into consideration the high volatility and hydrophobicity of perfluoro-octane and following the ISO 10993 guideline. Cytotoxicity test showed clear cytotoxic effects of the analysed batch (less than 9% of cell viability). Moreover, chemical analysis demonstrated the presence of many contaminants, some highly toxic (acids and alcohols). Perfluorocarbon liquids are useful tools for intraocular surgery but companies and Agencies of Medical Devices must implement measures that guarantee the safety of these products based on both chemical and cytotoxicity analysis for every batch. Medical staff should be encouraged to report any suspected case to their respective National Agencies.
format	article
author	Rosa M. Coco-Martin Cristina Andrés-Iglesias Girish K. Srivastava Javier Lagos-Rodriguez Miguel Ruiz-Tevah Mario R. Díaz-Cárdenas Ivan Fernandez-Bueno Juan García-Serna María T. García-Gutierrez Alfredo García-Layana J. Carlos Pastor
author_facet	Rosa M. Coco-Martin Cristina Andrés-Iglesias Girish K. Srivastava Javier Lagos-Rodriguez Miguel Ruiz-Tevah Mario R. Díaz-Cárdenas Ivan Fernandez-Bueno Juan García-Serna María T. García-Gutierrez Alfredo García-Layana J. Carlos Pastor
author_sort	Rosa M. Coco-Martin
title	Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid
title_short	Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid
title_full	Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid
title_fullStr	Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid
title_full_unstemmed	Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid
title_sort	intraocular toxicity caused by meroctane perfluorocarbon liquid
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ddf4756e74c45e995f2f7ace156f680
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Intraocular toxicity caused by MEROCTANE perfluorocarbon liquid

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