Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice
Nicotine withdrawal symptoms, mainly anxiety, cause high level of relapse rate after quitting smoking. Vitamin D supplementation has shown its potential for the prevention and treatment of anxiety disorders; however, neurobiological studies about the effect of vitamin D on nicotine withdrawal-induce...
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De Gruyter
2021
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oai:doaj.org-article:2de0c3b25e73436993231c99deb9847a2021-12-05T14:11:05ZVitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice2081-693610.1515/tnsci-2020-0166https://doaj.org/article/2de0c3b25e73436993231c99deb9847a2021-06-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0166https://doaj.org/toc/2081-6936Nicotine withdrawal symptoms, mainly anxiety, cause high level of relapse rate after quitting smoking. Vitamin D supplementation has shown its potential for the prevention and treatment of anxiety disorders; however, neurobiological studies about the effect of vitamin D on nicotine withdrawal-induced anxiety are limited. To investigate the effect and molecular mechanism of vitamin D3 supplement by dietary on anxiety-like behavior during nicotine withdrawal, male C57/BL6 mice were divided into four groups: vehicle, nicotine only, vitamin D3 only, and nicotine plus vitamin D3. Mice were administrated with nicotine in drinking water (200 µg/mL), and vitamin D3 in feed for 6 weeks. During nicotine withdrawal, vitamin D3-treated mice showed significantly less anxiety-like behavior by an open-field test and marble buried test that performed an increase in the duration of the central zone and a decrease buried marble, respectively. Moreover, vitamin D3 supplementation attenuated the hippocampal NR2A expression on both protein and mRNA levels in nicotine and vitamin D3-treated mice. Our data showed that dietary supplementation with vitamin D3 ameliorated nicotine withdrawal-induced anxiety, which may be related to downregulation of NR2A expression in hippocampus. Vitamin D3 may provide a new dietary intervention with the easy access for smoking cessation.Wu BingxueTao XinrongLiu ChuanlinLi HuaixuJiang TaoChen ZijunWang QiLiu FeiMu MinChen ZhaoyanDe Gruyterarticlenicotine withdrawalanxiety-like behaviorvitamin d3nr2ahippocampusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 273-281 (2021) |
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nicotine withdrawal anxiety-like behavior vitamin d3 nr2a hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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nicotine withdrawal anxiety-like behavior vitamin d3 nr2a hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Wu Bingxue Tao Xinrong Liu Chuanlin Li Huaixu Jiang Tao Chen Zijun Wang Qi Liu Fei Mu Min Chen Zhaoyan Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice |
description |
Nicotine withdrawal symptoms, mainly anxiety, cause high level of relapse rate after quitting smoking. Vitamin D supplementation has shown its potential for the prevention and treatment of anxiety disorders; however, neurobiological studies about the effect of vitamin D on nicotine withdrawal-induced anxiety are limited. To investigate the effect and molecular mechanism of vitamin D3 supplement by dietary on anxiety-like behavior during nicotine withdrawal, male C57/BL6 mice were divided into four groups: vehicle, nicotine only, vitamin D3 only, and nicotine plus vitamin D3. Mice were administrated with nicotine in drinking water (200 µg/mL), and vitamin D3 in feed for 6 weeks. During nicotine withdrawal, vitamin D3-treated mice showed significantly less anxiety-like behavior by an open-field test and marble buried test that performed an increase in the duration of the central zone and a decrease buried marble, respectively. Moreover, vitamin D3 supplementation attenuated the hippocampal NR2A expression on both protein and mRNA levels in nicotine and vitamin D3-treated mice. Our data showed that dietary supplementation with vitamin D3 ameliorated nicotine withdrawal-induced anxiety, which may be related to downregulation of NR2A expression in hippocampus. Vitamin D3 may provide a new dietary intervention with the easy access for smoking cessation. |
format |
article |
author |
Wu Bingxue Tao Xinrong Liu Chuanlin Li Huaixu Jiang Tao Chen Zijun Wang Qi Liu Fei Mu Min Chen Zhaoyan |
author_facet |
Wu Bingxue Tao Xinrong Liu Chuanlin Li Huaixu Jiang Tao Chen Zijun Wang Qi Liu Fei Mu Min Chen Zhaoyan |
author_sort |
Wu Bingxue |
title |
Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice |
title_short |
Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice |
title_full |
Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice |
title_fullStr |
Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice |
title_full_unstemmed |
Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice |
title_sort |
vitamin d3 reduces hippocampal nr2a and anxiety in nicotine withdrawal mice |
publisher |
De Gruyter |
publishDate |
2021 |
url |
https://doaj.org/article/2de0c3b25e73436993231c99deb9847a |
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