A p.Arg499His mutation in SPAST is associated with infantile-onset complicated spastic paraplegia: a case report and review of the literature
Abstract Background Spastic paraplegia type 4 (SPG4) is caused by mutations in the SPAST gene, is the most common form of autosomal-dominant pure hereditary spastic paraplegias (HSP), and is rarely associated with a complicated form that includes ataxia, epilepsy, and cognitive decline. To date, the...
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Auteurs principaux: | Haitian Nan, Hiroshi Shiraku, Tomoko Mizuno, Yoshihisa Takiyama |
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Format: | article |
Langue: | EN |
Publié: |
BMC
2021
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Accès en ligne: | https://doaj.org/article/2de1a4e4804d4d0097855afef05aabf7 |
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