Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries

Abstract The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S. muta...

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Autores principales:	Shuhei Naka, Kaoruko Wato, Taro Misaki, Seigo Ito, Daiki Matsuoka, Yasuyuki Nagasawa, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2de5884b3c754a328a9bc81bb633e8ad
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spelling	oai:doaj.org-article:2de5884b3c754a328a9bc81bb633e8ad2021-12-02T13:33:44ZStreptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries10.1038/s41598-021-85196-42045-2322https://doaj.org/article/2de5884b3c754a328a9bc81bb633e8ad2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85196-4https://doaj.org/toc/2045-2322Abstract The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S. mutans isolates that express Cnm protein on their cell surface were frequently detected in IgAN patients. In the present study, inoculation of Cnm-positive S. mutans in the oral cavities of 2-week-old specific-pathogen free Sprague–Dawley rats fed a high-sucrose diet for 32 weeks produced severe dental caries in all rats. Immunohistochemical analyses of the kidneys using IgA- and complement C3-specific antibodies revealed positive staining in the mesangial region. Scanning electron microscopy revealed a wide distribution of electron dense deposits in the mesangial region and periodic acid-Schiff staining demonstrated prominent proliferation of mesangial cells and mesangial matrix. These results suggest that IgAN-like glomerulonephritis was induced in rats with severe dental caries by Cnm-positive S. mutans.Shuhei NakaKaoruko WatoTaro MisakiSeigo ItoDaiki MatsuokaYasuyuki NagasawaRyota NomuraMichiyo Matsumoto-NakanoKazuhiko NakanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuhei Naka Kaoruko Wato Taro Misaki Seigo Ito Daiki Matsuoka Yasuyuki Nagasawa Ryota Nomura Michiyo Matsumoto-Nakano Kazuhiko Nakano Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries
description	Abstract The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S. mutans isolates that express Cnm protein on their cell surface were frequently detected in IgAN patients. In the present study, inoculation of Cnm-positive S. mutans in the oral cavities of 2-week-old specific-pathogen free Sprague–Dawley rats fed a high-sucrose diet for 32 weeks produced severe dental caries in all rats. Immunohistochemical analyses of the kidneys using IgA- and complement C3-specific antibodies revealed positive staining in the mesangial region. Scanning electron microscopy revealed a wide distribution of electron dense deposits in the mesangial region and periodic acid-Schiff staining demonstrated prominent proliferation of mesangial cells and mesangial matrix. These results suggest that IgAN-like glomerulonephritis was induced in rats with severe dental caries by Cnm-positive S. mutans.
format	article
author	Shuhei Naka Kaoruko Wato Taro Misaki Seigo Ito Daiki Matsuoka Yasuyuki Nagasawa Ryota Nomura Michiyo Matsumoto-Nakano Kazuhiko Nakano
author_facet	Shuhei Naka Kaoruko Wato Taro Misaki Seigo Ito Daiki Matsuoka Yasuyuki Nagasawa Ryota Nomura Michiyo Matsumoto-Nakano Kazuhiko Nakano
author_sort	Shuhei Naka
title	Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries
title_short	Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries
title_full	Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries
title_fullStr	Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries
title_full_unstemmed	Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries
title_sort	streptococcus mutans induces iga nephropathy-like glomerulonephritis in rats with severe dental caries
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2de5884b3c754a328a9bc81bb633e8ad
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Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries

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