Human ovarian reserve from conception to the menopause.

The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related population of NGFs in the human ovary from conception to menopause. D...

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Autores principales:	W Hamish B Wallace, Thomas W Kelsey
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2de6dca33aa849c58eadf409b3614551
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spelling	oai:doaj.org-article:2de6dca33aa849c58eadf409b36145512021-11-25T06:26:21ZHuman ovarian reserve from conception to the menopause.1932-620310.1371/journal.pone.0008772https://doaj.org/article/2de6dca33aa849c58eadf409b36145512010-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20111701/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related population of NGFs in the human ovary from conception to menopause. Data were taken from eight separate quantitative histological studies (n = 325) in which NGF populations at known ages from seven weeks post conception to 51 years (median 32 years) were calculated. The data set was fitted to 20 peak function models, with the results ranked by obtained r2 correlation coefficient. The highest ranked model was chosen. Our model matches the log-adjusted NGF population from conception to menopause to a five-parameter asymmetric double Gaussian cumulative (ADC) curve (r2 = 0.81). When restricted to ages up to 25 years, the ADC curve has r2 = 0.95. We estimate that for 95% of women by the age of 30 years only 12% of their maximum pre-birth NGF population is present and by the age of 40 years only 3% remains. Furthermore, we found that the rate of NGF recruitment towards maturation for most women increases from birth until approximately age 14 years then decreases towards the menopause. To our knowledge, this is the first model of ovarian reserve from conception to menopause. This model allows us to estimate the number of NGFs present in the ovary at any given age, suggests that 81% of the variance in NGF populations is due to age alone, and shows for the first time, to our knowledge, that the rate of NGF recruitment increases from birth to age 14 years then declines with age until menopause. An increased understanding of the dynamics of human ovarian reserve will provide a more scientific basis for fertility counselling for both healthy women and those who have survived gonadotoxic cancer treatments.W Hamish B WallaceThomas W KelseyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 1, p e8772 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q W Hamish B Wallace Thomas W Kelsey Human ovarian reserve from conception to the menopause.
description	The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related population of NGFs in the human ovary from conception to menopause. Data were taken from eight separate quantitative histological studies (n = 325) in which NGF populations at known ages from seven weeks post conception to 51 years (median 32 years) were calculated. The data set was fitted to 20 peak function models, with the results ranked by obtained r2 correlation coefficient. The highest ranked model was chosen. Our model matches the log-adjusted NGF population from conception to menopause to a five-parameter asymmetric double Gaussian cumulative (ADC) curve (r2 = 0.81). When restricted to ages up to 25 years, the ADC curve has r2 = 0.95. We estimate that for 95% of women by the age of 30 years only 12% of their maximum pre-birth NGF population is present and by the age of 40 years only 3% remains. Furthermore, we found that the rate of NGF recruitment towards maturation for most women increases from birth until approximately age 14 years then decreases towards the menopause. To our knowledge, this is the first model of ovarian reserve from conception to menopause. This model allows us to estimate the number of NGFs present in the ovary at any given age, suggests that 81% of the variance in NGF populations is due to age alone, and shows for the first time, to our knowledge, that the rate of NGF recruitment increases from birth to age 14 years then declines with age until menopause. An increased understanding of the dynamics of human ovarian reserve will provide a more scientific basis for fertility counselling for both healthy women and those who have survived gonadotoxic cancer treatments.
format	article
author	W Hamish B Wallace Thomas W Kelsey
author_facet	W Hamish B Wallace Thomas W Kelsey
author_sort	W Hamish B Wallace
title	Human ovarian reserve from conception to the menopause.
title_short	Human ovarian reserve from conception to the menopause.
title_full	Human ovarian reserve from conception to the menopause.
title_fullStr	Human ovarian reserve from conception to the menopause.
title_full_unstemmed	Human ovarian reserve from conception to the menopause.
title_sort	human ovarian reserve from conception to the menopause.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/2de6dca33aa849c58eadf409b3614551
work_keys_str_mv	AT whamishbwallace humanovarianreservefromconceptiontothemenopause AT thomaswkelsey humanovarianreservefromconceptiontothemenopause
_version_	1718413732341612544

Human ovarian reserve from conception to the menopause.

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