Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea

Context: Since there is still a great need to search for plant species with antinociceptive and anti-inflammatory activities, Diploptropis purpurea (Rich.) Amshoff (Fabaceae) is studied for the first time. Objective: This evaluates the analgesic and anti-inflammatory activities of the stem methanol...

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Autores principales:	Lorena A. Cruz, Miguel A. Díaz, Mahabir P. Gupta, José Luis López-Pérez, Eily Mondolis, Juan Morán-Pinzón, Estela Guerrero
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	fabaceae carrageenan paw oedema hot plate formalin test writhing test Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2de87d360d1e40f3ba660bc5498e3a73
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spelling	oai:doaj.org-article:2de87d360d1e40f3ba660bc5498e3a732021-11-17T14:21:56ZAssessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea1388-02091744-511610.1080/13880209.2019.1628074https://doaj.org/article/2de87d360d1e40f3ba660bc5498e3a732019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1628074https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Since there is still a great need to search for plant species with antinociceptive and anti-inflammatory activities, Diploptropis purpurea (Rich.) Amshoff (Fabaceae) is studied for the first time. Objective: This evaluates the analgesic and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea (MEDP). Material and methods: The anti-inflammatory and analgesic effects of MEDP of D. purpurea were evaluated in vivo. The antinociceptive activity was assessed in CD1 male mice were treated by oral gavage with 500 mg/kg of MEDP 30 min before submitting to acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Paws oedema induced by carrageenan, histamine or serotonin were performed in male Sprague–Dawley rats to determinate the anti-inflammatory activity. Results: Oral administration of MEDP produced significant antinociceptive effects on the inflammatory phase in the formalin test [12.0 s versus 72.5 s in carboxymethyl cellulose (CMC) control group]. MEDP produced an analgesic effect in the hot-plate model, although the effect was modest compared to tramadol (40 and 60%, respectively). The oral administration of MEDP in a dose of 500 mg/kg showed maximum inhibition (75.1%) after 0.5 h in carrageenan-induced oedema, but it did not modify histamine or serotonin-induced oedemas. Discussion and conclusion: In the peripheral nociception model, acetic acid-induced abdominal writhing, the MEDP did not show a protective effect, but its analgesic effects were evident in the inflammatory phase of the formalin test and in the hot-plate model. These results show that the anti-inflammatory effect was accompanied by a reduction in the perception of painful stimuli.Lorena A. CruzMiguel A. DíazMahabir P. GuptaJosé Luis López-PérezEily MondolisJuan Morán-PinzónEstela GuerreroTaylor & Francis Grouparticlefabaceaecarrageenanpaw oedemahot plateformalin testwrithing testTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 432-436 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	fabaceae carrageenan paw oedema hot plate formalin test writhing test Therapeutics. Pharmacology RM1-950
spellingShingle	fabaceae carrageenan paw oedema hot plate formalin test writhing test Therapeutics. Pharmacology RM1-950 Lorena A. Cruz Miguel A. Díaz Mahabir P. Gupta José Luis López-Pérez Eily Mondolis Juan Morán-Pinzón Estela Guerrero Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea
description	Context: Since there is still a great need to search for plant species with antinociceptive and anti-inflammatory activities, Diploptropis purpurea (Rich.) Amshoff (Fabaceae) is studied for the first time. Objective: This evaluates the analgesic and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea (MEDP). Material and methods: The anti-inflammatory and analgesic effects of MEDP of D. purpurea were evaluated in vivo. The antinociceptive activity was assessed in CD1 male mice were treated by oral gavage with 500 mg/kg of MEDP 30 min before submitting to acetic acid-induced abdominal writhing, hot-plate, and formalin tests. Paws oedema induced by carrageenan, histamine or serotonin were performed in male Sprague–Dawley rats to determinate the anti-inflammatory activity. Results: Oral administration of MEDP produced significant antinociceptive effects on the inflammatory phase in the formalin test [12.0 s versus 72.5 s in carboxymethyl cellulose (CMC) control group]. MEDP produced an analgesic effect in the hot-plate model, although the effect was modest compared to tramadol (40 and 60%, respectively). The oral administration of MEDP in a dose of 500 mg/kg showed maximum inhibition (75.1%) after 0.5 h in carrageenan-induced oedema, but it did not modify histamine or serotonin-induced oedemas. Discussion and conclusion: In the peripheral nociception model, acetic acid-induced abdominal writhing, the MEDP did not show a protective effect, but its analgesic effects were evident in the inflammatory phase of the formalin test and in the hot-plate model. These results show that the anti-inflammatory effect was accompanied by a reduction in the perception of painful stimuli.
format	article
author	Lorena A. Cruz Miguel A. Díaz Mahabir P. Gupta José Luis López-Pérez Eily Mondolis Juan Morán-Pinzón Estela Guerrero
author_facet	Lorena A. Cruz Miguel A. Díaz Mahabir P. Gupta José Luis López-Pérez Eily Mondolis Juan Morán-Pinzón Estela Guerrero
author_sort	Lorena A. Cruz
title	Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea
title_short	Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea
title_full	Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea
title_fullStr	Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea
title_full_unstemmed	Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea
title_sort	assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of diplotropis purpurea
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/2de87d360d1e40f3ba660bc5498e3a73
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Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea

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