Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 t...

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Autores principales: Konstantin Khetchoumian, Aurélio Balsalobre, Alexandre Mayran, Helen Christian, Valérie Chénard, Julie St-Pierre, Jacques Drouin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2ded1151fab64ba68a4d5db6a8ce4a72
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spelling oai:doaj.org-article:2ded1151fab64ba68a4d5db6a8ce4a722021-12-02T15:35:26ZPituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l210.1038/s41467-019-11894-32041-1723https://doaj.org/article/2ded1151fab64ba68a4d5db6a8ce4a722019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11894-3https://doaj.org/toc/2041-1723Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 to enhance translation and secretory capacities.Konstantin KhetchoumianAurélio BalsalobreAlexandre MayranHelen ChristianValérie ChénardJulie St-PierreJacques DrouinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Konstantin Khetchoumian
Aurélio Balsalobre
Alexandre Mayran
Helen Christian
Valérie Chénard
Julie St-Pierre
Jacques Drouin
Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
description Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 to enhance translation and secretory capacities.
format article
author Konstantin Khetchoumian
Aurélio Balsalobre
Alexandre Mayran
Helen Christian
Valérie Chénard
Julie St-Pierre
Jacques Drouin
author_facet Konstantin Khetchoumian
Aurélio Balsalobre
Alexandre Mayran
Helen Christian
Valérie Chénard
Julie St-Pierre
Jacques Drouin
author_sort Konstantin Khetchoumian
title Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_short Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_full Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_fullStr Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_full_unstemmed Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2
title_sort pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor creb3l2
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2ded1151fab64ba68a4d5db6a8ce4a72
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AT aureliobalsalobre pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
AT alexandremayran pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
AT helenchristian pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
AT valeriechenard pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
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AT jacquesdrouin pituitarycelltranslationandsecretorycapacitiesareenhancedcellautonomouslybythetranscriptionfactorcreb3l2
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