Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2

Pituitary POMC secreting cells achieve high hormone expression levels after birth but the mechanism for this regulation is unclear. Here, the authors show that this process is driven cell autonomously by the differentiation factor Tpit that activates the bZIP transcription factors Creb3l2 and XBP1 t...

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Autores principales: Konstantin Khetchoumian, Aurélio Balsalobre, Alexandre Mayran, Helen Christian, Valérie Chénard, Julie St-Pierre, Jacques Drouin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2ded1151fab64ba68a4d5db6a8ce4a72
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