Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance...

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Autores principales:	Mahshid Deldar Abad Paskeh, Shafagh Asadi, Amirhossein Zabolian, Hossein Saleki, Mohammad Amin Khoshbakht, Sina Sabet, Mohamad Javad Naghdi, Mehrdad Hashemi, Kiavash Hushmandi, Milad Ashrafizadeh, Sepideh Mirzaei, Ali Zarrabi, Gautam Sethi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	medicinal herbs cancer treatment cancer stem cells drug resistance metastasis proliferation Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2defa0538fa94307a316b027a15c48ca
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spelling	oai:doaj.org-article:2defa0538fa94307a316b027a15c48ca2021-11-11T17:08:04ZTargeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies10.3390/ijms2221116691422-00671661-6596https://doaj.org/article/2defa0538fa94307a316b027a15c48ca2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11669https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.Mahshid Deldar Abad PaskehShafagh AsadiAmirhossein ZabolianHossein SalekiMohammad Amin KhoshbakhtSina SabetMohamad Javad NaghdiMehrdad HashemiKiavash HushmandiMilad AshrafizadehSepideh MirzaeiAli ZarrabiGautam SethiMDPI AGarticlemedicinal herbscancer treatmentcancer stem cellsdrug resistancemetastasisproliferationBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11669, p 11669 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	medicinal herbs cancer treatment cancer stem cells drug resistance metastasis proliferation Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	medicinal herbs cancer treatment cancer stem cells drug resistance metastasis proliferation Biology (General) QH301-705.5 Chemistry QD1-999 Mahshid Deldar Abad Paskeh Shafagh Asadi Amirhossein Zabolian Hossein Saleki Mohammad Amin Khoshbakht Sina Sabet Mohamad Javad Naghdi Mehrdad Hashemi Kiavash Hushmandi Milad Ashrafizadeh Sepideh Mirzaei Ali Zarrabi Gautam Sethi Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies
description	As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.
format	article
author	Mahshid Deldar Abad Paskeh Shafagh Asadi Amirhossein Zabolian Hossein Saleki Mohammad Amin Khoshbakht Sina Sabet Mohamad Javad Naghdi Mehrdad Hashemi Kiavash Hushmandi Milad Ashrafizadeh Sepideh Mirzaei Ali Zarrabi Gautam Sethi
author_facet	Mahshid Deldar Abad Paskeh Shafagh Asadi Amirhossein Zabolian Hossein Saleki Mohammad Amin Khoshbakht Sina Sabet Mohamad Javad Naghdi Mehrdad Hashemi Kiavash Hushmandi Milad Ashrafizadeh Sepideh Mirzaei Ali Zarrabi Gautam Sethi
author_sort	Mahshid Deldar Abad Paskeh
title	Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies
title_short	Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies
title_full	Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies
title_fullStr	Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies
title_full_unstemmed	Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies
title_sort	targeting cancer stem cells by dietary agents: an important therapeutic strategy against human malignancies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2defa0538fa94307a316b027a15c48ca
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Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

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