The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis

Background. In recent years, the incidence of colorectal cancer (CRC) has continued to increase. Although the overall prognosis of CRC has improved with the continuous improvement of the level of treatment, the prognosis of metastatic colorectal cancer (mCRC) is still poor. The purpose of our study...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jinming Wang, Jing Li, Sheng Wei, Jie Xu, Xiaohui Jiang, Lei Yang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/2df087dde59845fcbcd45ef4647fc379
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2df087dde59845fcbcd45ef4647fc379
record_format	dspace
spelling	oai:doaj.org-article:2df087dde59845fcbcd45ef4647fc3792021-11-15T01:19:13ZThe Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis1687-630X10.1155/2021/9699499https://doaj.org/article/2df087dde59845fcbcd45ef4647fc3792021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9699499https://doaj.org/toc/1687-630XBackground. In recent years, the incidence of colorectal cancer (CRC) has continued to increase. Although the overall prognosis of CRC has improved with the continuous improvement of the level of treatment, the prognosis of metastatic colorectal cancer (mCRC) is still poor. The purpose of our study is to explore the prognostic value of platelet to lymphocyte ratio (PLR) in mCRC. Methods. The PubMed, Web of Science, and Embase (via OVID) were systematically searched to obtain all relevant research. We used hazard ratio (HR) with 95% confidence interval (CI) to assess the associations of PLR and overall survival (OS) and progression free survival (PFS). Results. A total of twelve studies containing 1452 patients were included in this meta-analysis. Pooled analysis showed that high levels of PLR were associated with poor OS (HR: 1.72, 95% CI: 1.27–2.33, and P<0.01) and PFS (HR: 1.64, 95% CI: 1.16–2.31, and P=0.033). Conclusion. Our analysis suggested that high levels of PLR pretreatment may be an effective predictive biomarker for the prognosis of mCRC patients.Jinming WangJing LiSheng WeiJie XuXiaohui JiangLei YangHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENGastroenterology Research and Practice, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Jinming Wang Jing Li Sheng Wei Jie Xu Xiaohui Jiang Lei Yang The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis
description	Background. In recent years, the incidence of colorectal cancer (CRC) has continued to increase. Although the overall prognosis of CRC has improved with the continuous improvement of the level of treatment, the prognosis of metastatic colorectal cancer (mCRC) is still poor. The purpose of our study is to explore the prognostic value of platelet to lymphocyte ratio (PLR) in mCRC. Methods. The PubMed, Web of Science, and Embase (via OVID) were systematically searched to obtain all relevant research. We used hazard ratio (HR) with 95% confidence interval (CI) to assess the associations of PLR and overall survival (OS) and progression free survival (PFS). Results. A total of twelve studies containing 1452 patients were included in this meta-analysis. Pooled analysis showed that high levels of PLR were associated with poor OS (HR: 1.72, 95% CI: 1.27–2.33, and P<0.01) and PFS (HR: 1.64, 95% CI: 1.16–2.31, and P=0.033). Conclusion. Our analysis suggested that high levels of PLR pretreatment may be an effective predictive biomarker for the prognosis of mCRC patients.
format	article
author	Jinming Wang Jing Li Sheng Wei Jie Xu Xiaohui Jiang Lei Yang
author_facet	Jinming Wang Jing Li Sheng Wei Jie Xu Xiaohui Jiang Lei Yang
author_sort	Jinming Wang
title	The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis
title_short	The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis
title_full	The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis
title_fullStr	The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis
title_full_unstemmed	The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis
title_sort	ratio of platelets to lymphocytes predicts the prognosis of metastatic colorectal cancer: a review and meta-analysis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/2df087dde59845fcbcd45ef4647fc379
work_keys_str_mv	AT jinmingwang theratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT jingli theratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT shengwei theratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT jiexu theratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT xiaohuijiang theratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT leiyang theratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT jinmingwang ratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT jingli ratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT shengwei ratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT jiexu ratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT xiaohuijiang ratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis AT leiyang ratioofplateletstolymphocytespredictstheprognosisofmetastaticcolorectalcancerareviewandmetaanalysis
_version_	1718428972537085952

The Ratio of Platelets to Lymphocytes Predicts the Prognosis of Metastatic Colorectal Cancer: A Review and Meta-Analysis

Ejemplares similares