Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.

The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T)...

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Autores principales:	Filip Růžička, Robert Jech, Lucie Nováková, Dušan Urgošík, Josef Vymazal, Evžen Růžička
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2df0abd934d34184be067606085f955d
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spelling	oai:doaj.org-article:2df0abd934d34184be067606085f955d2021-11-18T07:16:55ZWeight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.1932-620310.1371/journal.pone.0038020https://doaj.org/article/2df0abd934d34184be067606085f955d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666437/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T) magnetic resonance images were used to determine electrode position in the subthalamic nucleus and the Unified Parkinson's disease rating scale (UPDRS-III) was used for motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely correlated with weight gain (r = -0.55, p<0.01) and with neurostimulation-related motor condition expressed as the contralateral hemi-body UPDRS-III (r = -0.42, p<0.01). Patients with at least one contact within 9.3 mm of the wall experienced significantly greater weight gain (9.4 ± (SD)4.4 kg, N = 11) than those with both contacts located laterally (3.9 ± 2.7 kg, N = 9) (p<0.001). The position of the active contact is critical not only for motor outcome but is also associated with weight gain, suggesting a regional effect of subthalamic stimulation on adjacent structures involved in the central regulation of energy balance, food intake or reward.Filip RůžičkaRobert JechLucie NovákováDušan UrgošíkJosef VymazalEvžen RůžičkaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e38020 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Filip Růžička Robert Jech Lucie Nováková Dušan Urgošík Josef Vymazal Evžen Růžička Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.
description	The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T) magnetic resonance images were used to determine electrode position in the subthalamic nucleus and the Unified Parkinson's disease rating scale (UPDRS-III) was used for motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely correlated with weight gain (r = -0.55, p<0.01) and with neurostimulation-related motor condition expressed as the contralateral hemi-body UPDRS-III (r = -0.42, p<0.01). Patients with at least one contact within 9.3 mm of the wall experienced significantly greater weight gain (9.4 ± (SD)4.4 kg, N = 11) than those with both contacts located laterally (3.9 ± 2.7 kg, N = 9) (p<0.001). The position of the active contact is critical not only for motor outcome but is also associated with weight gain, suggesting a regional effect of subthalamic stimulation on adjacent structures involved in the central regulation of energy balance, food intake or reward.
format	article
author	Filip Růžička Robert Jech Lucie Nováková Dušan Urgošík Josef Vymazal Evžen Růžička
author_facet	Filip Růžička Robert Jech Lucie Nováková Dušan Urgošík Josef Vymazal Evžen Růžička
author_sort	Filip Růžička
title	Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.
title_short	Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.
title_full	Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.
title_fullStr	Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.
title_full_unstemmed	Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.
title_sort	weight gain is associated with medial contact site of subthalamic stimulation in parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2df0abd934d34184be067606085f955d
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Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.

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