SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE

Thymectomy is a stage of surgery when treating some congenital heart defects. Thymus gland is the central organ of immune system. This organ is the primary site of T-cell lymphopoiesis and central tolerance to autoantigens during fetal and early postnatal life. If performed neonatally or in infancy,...

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Autores principales:	Yu. I. Rovda, S. A. Shmulevich, A. V. Shabaldin, E. B. Lukoyanycheva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	congenital heart anomalies thymectomy cd31 cd45ra Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2df1ff817a8543dc8d209ccf1d34a2d4
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spelling	oai:doaj.org-article:2df1ff817a8543dc8d209ccf1d34a2d42021-11-18T08:03:45ZSUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE1563-06252313-741X10.15789/1563-0625-2016-2-119-128https://doaj.org/article/2df1ff817a8543dc8d209ccf1d34a2d42016-04-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/995https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThymectomy is a stage of surgery when treating some congenital heart defects. Thymus gland is the central organ of immune system. This organ is the primary site of T-cell lymphopoiesis and central tolerance to autoantigens during fetal and early postnatal life. If performed neonatally or in infancy, the thymectomy may cause restriction of these immune functions. Suppression of T-cell lymphopoiesis in children with thymectomy can be estimated as a subpopulation of thymic naive T helper cells (CD3+CD4+CD45RA+CD31+). To perform this task, we evaluated subpopulations of thymic naive T helper lymphocytes with CD3+CD4+CD45RA+CD31+ phenotype in the children (n = 40) who underwent thymectomy during surgical treatment of congenital heart diseases in neonates, or in early postnatal life. Their data were compared with children who underwent surgical treatment of congenital heart disease without thymectomy at the same age periods (n = 12), and healthy children (n = 23). We have revealed that thymectomy in frames of surgery of congenital heart disease leads to reduced thymic naive T helper lymphocytes with CD3+CD4+CD45RA+CD31+ phenotype in peripheral blood. Early execution of thymectomy is associated with deficiency of the thymic naive T helper lymphocytes in the peripheral blood, as well as a decrease in T helper cells (CD3+CD4+). The number thymic naive T helper lymphocytes in peripheral blood negatively corrrelated with terms elapsed after the surgery of congenital heart defects in children.Yu. I. RovdaS. A. ShmulevichA. V. ShabaldinE. B. LukoyanychevaSPb RAACIarticlecongenital heart anomaliesthymectomycd31cd45raImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 2, Pp 119-128 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	congenital heart anomalies thymectomy cd31 cd45ra Immunologic diseases. Allergy RC581-607
spellingShingle	congenital heart anomalies thymectomy cd31 cd45ra Immunologic diseases. Allergy RC581-607 Yu. I. Rovda S. A. Shmulevich A. V. Shabaldin E. B. Lukoyanycheva SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE
description	Thymectomy is a stage of surgery when treating some congenital heart defects. Thymus gland is the central organ of immune system. This organ is the primary site of T-cell lymphopoiesis and central tolerance to autoantigens during fetal and early postnatal life. If performed neonatally or in infancy, the thymectomy may cause restriction of these immune functions. Suppression of T-cell lymphopoiesis in children with thymectomy can be estimated as a subpopulation of thymic naive T helper cells (CD3+CD4+CD45RA+CD31+). To perform this task, we evaluated subpopulations of thymic naive T helper lymphocytes with CD3+CD4+CD45RA+CD31+ phenotype in the children (n = 40) who underwent thymectomy during surgical treatment of congenital heart diseases in neonates, or in early postnatal life. Their data were compared with children who underwent surgical treatment of congenital heart disease without thymectomy at the same age periods (n = 12), and healthy children (n = 23). We have revealed that thymectomy in frames of surgery of congenital heart disease leads to reduced thymic naive T helper lymphocytes with CD3+CD4+CD45RA+CD31+ phenotype in peripheral blood. Early execution of thymectomy is associated with deficiency of the thymic naive T helper lymphocytes in the peripheral blood, as well as a decrease in T helper cells (CD3+CD4+). The number thymic naive T helper lymphocytes in peripheral blood negatively corrrelated with terms elapsed after the surgery of congenital heart defects in children.
format	article
author	Yu. I. Rovda S. A. Shmulevich A. V. Shabaldin E. B. Lukoyanycheva
author_facet	Yu. I. Rovda S. A. Shmulevich A. V. Shabaldin E. B. Lukoyanycheva
author_sort	Yu. I. Rovda
title	SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE
title_short	SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE
title_full	SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE
title_fullStr	SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE
title_full_unstemmed	SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE
title_sort	subpopulation profiles of t helper cells expressing cd45ra and cd31 markers in children after thymectomy performed upon surgical treatment of congenital heart disease
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/2df1ff817a8543dc8d209ccf1d34a2d4
work_keys_str_mv	AT yuirovda subpopulationprofilesofthelpercellsexpressingcd45raandcd31markersinchildrenafterthymectomyperformeduponsurgicaltreatmentofcongenitalheartdisease AT sashmulevich subpopulationprofilesofthelpercellsexpressingcd45raandcd31markersinchildrenafterthymectomyperformeduponsurgicaltreatmentofcongenitalheartdisease AT avshabaldin subpopulationprofilesofthelpercellsexpressingcd45raandcd31markersinchildrenafterthymectomyperformeduponsurgicaltreatmentofcongenitalheartdisease AT eblukoyanycheva subpopulationprofilesofthelpercellsexpressingcd45raandcd31markersinchildrenafterthymectomyperformeduponsurgicaltreatmentofcongenitalheartdisease
_version_	1718422406770458624

SUBPOPULATION PROFILES OF T HELPER CELLS EXPRESSING CD45RA AND CD31 MARKERS IN CHILDREN AFTER THYMECTOMY PERFORMED UPON SURGICAL TREATMENT OF CONGENITAL HEART DISEASE

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