Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up

Abstract The aim of this study was to cross-sectionally and longitudinally examine whether higher hemoglobin (Hb) levels within the normal variation associate with key components of metabolic syndrome and total and cardiovascular mortality. The study included 967 Finnish subjects (age 40–59 years) f...

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Autores principales:	Joona Tapio, Hannu Vähänikkilä, Y. Antero Kesäniemi, Olavi Ukkola, Peppi Koivunen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2df2abe26db24b298a70f53a6afc7b56
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spelling	oai:doaj.org-article:2df2abe26db24b298a70f53a6afc7b562021-12-02T18:01:48ZHigher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up10.1038/s41598-021-99217-92045-2322https://doaj.org/article/2df2abe26db24b298a70f53a6afc7b562021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99217-9https://doaj.org/toc/2045-2322Abstract The aim of this study was to cross-sectionally and longitudinally examine whether higher hemoglobin (Hb) levels within the normal variation associate with key components of metabolic syndrome and total and cardiovascular mortality. The study included 967 Finnish subjects (age 40–59 years) followed for ≥ 20 years. The focus was on Hb levels, cardiovascular diseases (CVDs) and mortality rates. Higher Hb levels associated positively with key anthropometric and metabolic parameters at baseline. At the follow-up similar associations were seen in men. The highest Hb quartile showed higher leptin levels and lower adiponectin levels at baseline and follow-up (p < 0.05) and lower plasma ghrelin levels at baseline (p < 0.05). Higher baseline Hb levels associated independently with prevalence of type 2 diabetes at follow-up (p < 0.01). The highest Hb quartile associated with higher serum alanine aminotransferase levels (p < 0.001) and independently with increased risk for liver fat accumulation (OR 1.63 [1.03; 2.57]) at baseline. The highest Hb quartile showed increased risk for total (HR = 1.48 [1.01; 2.16]) and CVD-related mortality (HR = 2.08 [1.01; 4.29]). Higher Hb levels associated with an adverse metabolic profile, increased prevalence of key components of metabolic syndrome and higher risk for CVD-related and total mortality.Joona TapioHannu VähänikkiläY. Antero KesäniemiOlavi UkkolaPeppi KoivunenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joona Tapio Hannu Vähänikkilä Y. Antero Kesäniemi Olavi Ukkola Peppi Koivunen Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up
description	Abstract The aim of this study was to cross-sectionally and longitudinally examine whether higher hemoglobin (Hb) levels within the normal variation associate with key components of metabolic syndrome and total and cardiovascular mortality. The study included 967 Finnish subjects (age 40–59 years) followed for ≥ 20 years. The focus was on Hb levels, cardiovascular diseases (CVDs) and mortality rates. Higher Hb levels associated positively with key anthropometric and metabolic parameters at baseline. At the follow-up similar associations were seen in men. The highest Hb quartile showed higher leptin levels and lower adiponectin levels at baseline and follow-up (p < 0.05) and lower plasma ghrelin levels at baseline (p < 0.05). Higher baseline Hb levels associated independently with prevalence of type 2 diabetes at follow-up (p < 0.01). The highest Hb quartile associated with higher serum alanine aminotransferase levels (p < 0.001) and independently with increased risk for liver fat accumulation (OR 1.63 [1.03; 2.57]) at baseline. The highest Hb quartile showed increased risk for total (HR = 1.48 [1.01; 2.16]) and CVD-related mortality (HR = 2.08 [1.01; 4.29]). Higher Hb levels associated with an adverse metabolic profile, increased prevalence of key components of metabolic syndrome and higher risk for CVD-related and total mortality.
format	article
author	Joona Tapio Hannu Vähänikkilä Y. Antero Kesäniemi Olavi Ukkola Peppi Koivunen
author_facet	Joona Tapio Hannu Vähänikkilä Y. Antero Kesäniemi Olavi Ukkola Peppi Koivunen
author_sort	Joona Tapio
title	Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up
title_short	Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up
title_full	Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up
title_fullStr	Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up
title_full_unstemmed	Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up
title_sort	higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2df2abe26db24b298a70f53a6afc7b56
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Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up

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