Expanding C–T base editing toolkit with diversified cytidine deaminases

Cytosine base editors are limited by editing scope and potential off-target effects. Here the authors screen diversified lamprey cytidine deaminases along with different protein fusion architectures and present base editors with improved fidelity.

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Autores principales:	Tian-Lin Cheng, Shuo Li, Bo Yuan, Xiaolin Wang, Wenhao Zhou, Zilong Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2df32f7847ab4da0971e6e9829691357
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spelling	oai:doaj.org-article:2df32f7847ab4da0971e6e98296913572021-12-02T14:39:57ZExpanding C–T base editing toolkit with diversified cytidine deaminases10.1038/s41467-019-11562-62041-1723https://doaj.org/article/2df32f7847ab4da0971e6e98296913572019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11562-6https://doaj.org/toc/2041-1723Cytosine base editors are limited by editing scope and potential off-target effects. Here the authors screen diversified lamprey cytidine deaminases along with different protein fusion architectures and present base editors with improved fidelity.Tian-Lin ChengShuo LiBo YuanXiaolin WangWenhao ZhouZilong QiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tian-Lin Cheng Shuo Li Bo Yuan Xiaolin Wang Wenhao Zhou Zilong Qiu Expanding C–T base editing toolkit with diversified cytidine deaminases
description	Cytosine base editors are limited by editing scope and potential off-target effects. Here the authors screen diversified lamprey cytidine deaminases along with different protein fusion architectures and present base editors with improved fidelity.
format	article
author	Tian-Lin Cheng Shuo Li Bo Yuan Xiaolin Wang Wenhao Zhou Zilong Qiu
author_facet	Tian-Lin Cheng Shuo Li Bo Yuan Xiaolin Wang Wenhao Zhou Zilong Qiu
author_sort	Tian-Lin Cheng
title	Expanding C–T base editing toolkit with diversified cytidine deaminases
title_short	Expanding C–T base editing toolkit with diversified cytidine deaminases
title_full	Expanding C–T base editing toolkit with diversified cytidine deaminases
title_fullStr	Expanding C–T base editing toolkit with diversified cytidine deaminases
title_full_unstemmed	Expanding C–T base editing toolkit with diversified cytidine deaminases
title_sort	expanding c–t base editing toolkit with diversified cytidine deaminases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2df32f7847ab4da0971e6e9829691357
work_keys_str_mv	AT tianlincheng expandingctbaseeditingtoolkitwithdiversifiedcytidinedeaminases AT shuoli expandingctbaseeditingtoolkitwithdiversifiedcytidinedeaminases AT boyuan expandingctbaseeditingtoolkitwithdiversifiedcytidinedeaminases AT xiaolinwang expandingctbaseeditingtoolkitwithdiversifiedcytidinedeaminases AT wenhaozhou expandingctbaseeditingtoolkitwithdiversifiedcytidinedeaminases AT zilongqiu expandingctbaseeditingtoolkitwithdiversifiedcytidinedeaminases
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Expanding C–T base editing toolkit with diversified cytidine deaminases

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