Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron degenerative disease, and it is hard to diagnose in the early stage, and treatment means are limited, and the treatment effect is unsatisfactory. Therefore, exploring a new effective treatment strategy is urgently needed for...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ke Wang, Yu Li, Chao Ren, Yongjing Wang, Wenshan He, Yuan Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	amyotrophic lateral sclerosis extracellular vesicles treatment strategy exosome-mimics plant EVs Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2df7ed3651d94027b14a51bfe69adeef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2df7ed3651d94027b14a51bfe69adeef
record_format	dspace
spelling	oai:doaj.org-article:2df7ed3651d94027b14a51bfe69adeef2021-11-11T10:09:43ZExtracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis2296-634X10.3389/fcell.2021.754630https://doaj.org/article/2df7ed3651d94027b14a51bfe69adeef2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.754630/fullhttps://doaj.org/toc/2296-634XAmyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron degenerative disease, and it is hard to diagnose in the early stage, and treatment means are limited, and the treatment effect is unsatisfactory. Therefore, exploring a new effective treatment strategy is urgently needed for ALS patients. Extracellular vesicles (EVs) are a heterogeneous group of natural membrane vesicles containing many bioactive substances, and they play important roles in the paracrine pathway and exhibit neuroprotection effects. A growing body of evidence shows that EVs have great application potential in diagnosis, treatment, and drug delivery in ALS, and they represent an innovative treatment strategy for ALS. In this review, we will briefly introduce the biogenesis of EVs and focus on discussing the role of EVs in ALS treatment to further enrich and boost the development of EVs as an innovative treatment strategy for ALS.Ke WangYu LiChao RenYongjing WangWenshan HeYuan JiangFrontiers Media S.A.articleamyotrophic lateral sclerosisextracellular vesiclestreatment strategyexosome-mimicsplant EVsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amyotrophic lateral sclerosis extracellular vesicles treatment strategy exosome-mimics plant EVs Biology (General) QH301-705.5
spellingShingle	amyotrophic lateral sclerosis extracellular vesicles treatment strategy exosome-mimics plant EVs Biology (General) QH301-705.5 Ke Wang Yu Li Chao Ren Yongjing Wang Wenshan He Yuan Jiang Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis
description	Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron degenerative disease, and it is hard to diagnose in the early stage, and treatment means are limited, and the treatment effect is unsatisfactory. Therefore, exploring a new effective treatment strategy is urgently needed for ALS patients. Extracellular vesicles (EVs) are a heterogeneous group of natural membrane vesicles containing many bioactive substances, and they play important roles in the paracrine pathway and exhibit neuroprotection effects. A growing body of evidence shows that EVs have great application potential in diagnosis, treatment, and drug delivery in ALS, and they represent an innovative treatment strategy for ALS. In this review, we will briefly introduce the biogenesis of EVs and focus on discussing the role of EVs in ALS treatment to further enrich and boost the development of EVs as an innovative treatment strategy for ALS.
format	article
author	Ke Wang Yu Li Chao Ren Yongjing Wang Wenshan He Yuan Jiang
author_facet	Ke Wang Yu Li Chao Ren Yongjing Wang Wenshan He Yuan Jiang
author_sort	Ke Wang
title	Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis
title_short	Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis
title_full	Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis
title_fullStr	Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis
title_full_unstemmed	Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis
title_sort	extracellular vesicles as innovative treatment strategy for amyotrophic lateral sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2df7ed3651d94027b14a51bfe69adeef
work_keys_str_mv	AT kewang extracellularvesiclesasinnovativetreatmentstrategyforamyotrophiclateralsclerosis AT yuli extracellularvesiclesasinnovativetreatmentstrategyforamyotrophiclateralsclerosis AT chaoren extracellularvesiclesasinnovativetreatmentstrategyforamyotrophiclateralsclerosis AT yongjingwang extracellularvesiclesasinnovativetreatmentstrategyforamyotrophiclateralsclerosis AT wenshanhe extracellularvesiclesasinnovativetreatmentstrategyforamyotrophiclateralsclerosis AT yuanjiang extracellularvesiclesasinnovativetreatmentstrategyforamyotrophiclateralsclerosis
_version_	1718439201529135104

Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis

Ejemplares similares