Population-specific causal disease effect sizes in functionally important regions impacted by selection

Trans-ethnic genetic correlation is significantly less than 1 for many diseases. Here, the authors stratify this correlation by genomic annotations, finding that loci whose causal disease effect sizes differ between ethnicities are likely impacted by selection, particularly positive selection.

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Autores principales:	Huwenbo Shi, Steven Gazal, Masahiro Kanai, Evan M. Koch, Armin P. Schoech, Katherine M. Siewert, Samuel S. Kim, Yang Luo, Tiffany Amariuta, Hailiang Huang, Yukinori Okada, Soumya Raychaudhuri, Shamil R. Sunyaev, Alkes L. Price
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2dfa2cb15c014c84868e29d583709f8c
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spelling	oai:doaj.org-article:2dfa2cb15c014c84868e29d583709f8c2021-12-02T14:21:27ZPopulation-specific causal disease effect sizes in functionally important regions impacted by selection10.1038/s41467-021-21286-12041-1723https://doaj.org/article/2dfa2cb15c014c84868e29d583709f8c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21286-1https://doaj.org/toc/2041-1723Trans-ethnic genetic correlation is significantly less than 1 for many diseases. Here, the authors stratify this correlation by genomic annotations, finding that loci whose causal disease effect sizes differ between ethnicities are likely impacted by selection, particularly positive selection.Huwenbo ShiSteven GazalMasahiro KanaiEvan M. KochArmin P. SchoechKatherine M. SiewertSamuel S. KimYang LuoTiffany AmariutaHailiang HuangYukinori OkadaSoumya RaychaudhuriShamil R. SunyaevAlkes L. PriceNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huwenbo Shi Steven Gazal Masahiro Kanai Evan M. Koch Armin P. Schoech Katherine M. Siewert Samuel S. Kim Yang Luo Tiffany Amariuta Hailiang Huang Yukinori Okada Soumya Raychaudhuri Shamil R. Sunyaev Alkes L. Price Population-specific causal disease effect sizes in functionally important regions impacted by selection
description	Trans-ethnic genetic correlation is significantly less than 1 for many diseases. Here, the authors stratify this correlation by genomic annotations, finding that loci whose causal disease effect sizes differ between ethnicities are likely impacted by selection, particularly positive selection.
format	article
author	Huwenbo Shi Steven Gazal Masahiro Kanai Evan M. Koch Armin P. Schoech Katherine M. Siewert Samuel S. Kim Yang Luo Tiffany Amariuta Hailiang Huang Yukinori Okada Soumya Raychaudhuri Shamil R. Sunyaev Alkes L. Price
author_facet	Huwenbo Shi Steven Gazal Masahiro Kanai Evan M. Koch Armin P. Schoech Katherine M. Siewert Samuel S. Kim Yang Luo Tiffany Amariuta Hailiang Huang Yukinori Okada Soumya Raychaudhuri Shamil R. Sunyaev Alkes L. Price
author_sort	Huwenbo Shi
title	Population-specific causal disease effect sizes in functionally important regions impacted by selection
title_short	Population-specific causal disease effect sizes in functionally important regions impacted by selection
title_full	Population-specific causal disease effect sizes in functionally important regions impacted by selection
title_fullStr	Population-specific causal disease effect sizes in functionally important regions impacted by selection
title_full_unstemmed	Population-specific causal disease effect sizes in functionally important regions impacted by selection
title_sort	population-specific causal disease effect sizes in functionally important regions impacted by selection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2dfa2cb15c014c84868e29d583709f8c
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Population-specific causal disease effect sizes in functionally important regions impacted by selection

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