Population-specific causal disease effect sizes in functionally important regions impacted by selection
Trans-ethnic genetic correlation is significantly less than 1 for many diseases. Here, the authors stratify this correlation by genomic annotations, finding that loci whose causal disease effect sizes differ between ethnicities are likely impacted by selection, particularly positive selection.
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2021
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/2dfa2cb15c014c84868e29d583709f8c |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|