Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions

Antibodies are generated through remote genomic interactions involving immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. Here the authors develop a strategy to track VH-DHJH motion in B-lymphocytes and provide evidence that chromosome organisation near the sol-gel phase tr...

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Autores principales:	Nimish Khanna, Yaojun Zhang, Joseph S. Lucas, Olga K. Dudko, Cornelis Murre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2dfa8f0bd53543c2aca9b052523fc988
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spelling	oai:doaj.org-article:2dfa8f0bd53543c2aca9b052523fc9882021-12-02T14:39:16ZChromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions10.1038/s41467-019-10628-92041-1723https://doaj.org/article/2dfa8f0bd53543c2aca9b052523fc9882019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10628-9https://doaj.org/toc/2041-1723Antibodies are generated through remote genomic interactions involving immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. Here the authors develop a strategy to track VH-DHJH motion in B-lymphocytes and provide evidence that chromosome organisation near the sol-gel phase transition dictates the timing of genomic interactions to orchestrate gene expression and somatic recombination.Nimish KhannaYaojun ZhangJoseph S. LucasOlga K. DudkoCornelis MurreNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nimish Khanna Yaojun Zhang Joseph S. Lucas Olga K. Dudko Cornelis Murre Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
description	Antibodies are generated through remote genomic interactions involving immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. Here the authors develop a strategy to track VH-DHJH motion in B-lymphocytes and provide evidence that chromosome organisation near the sol-gel phase transition dictates the timing of genomic interactions to orchestrate gene expression and somatic recombination.
format	article
author	Nimish Khanna Yaojun Zhang Joseph S. Lucas Olga K. Dudko Cornelis Murre
author_facet	Nimish Khanna Yaojun Zhang Joseph S. Lucas Olga K. Dudko Cornelis Murre
author_sort	Nimish Khanna
title	Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
title_short	Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
title_full	Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
title_fullStr	Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
title_full_unstemmed	Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
title_sort	chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2dfa8f0bd53543c2aca9b052523fc988
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Chromosome dynamics near the sol-gel phase transition dictate the timing of remote genomic interactions

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