Night and day variations of sleep in patients with disorders of consciousness

Abstract Brain injuries substantially change the entire landscape of oscillatory dynamics and render detection of typical sleep patterns difficult. Yet, sleep is characterized not only by specific EEG waveforms, but also by its circadian organization. In the present study we investigated whether bra...

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Autores principales:	Malgorzata Wislowska, Renata del Giudice, Julia Lechinger, Tomasz Wielek, Dominik P. J. Heib, Alain Pitiot, Gerald Pichler, Gabriele Michitsch, Johann Donis, Manuel Schabus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2dfdc18ab8c24c8eb48a8c45ac768d5a
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spelling	oai:doaj.org-article:2dfdc18ab8c24c8eb48a8c45ac768d5a2021-12-02T16:06:39ZNight and day variations of sleep in patients with disorders of consciousness10.1038/s41598-017-00323-42045-2322https://doaj.org/article/2dfdc18ab8c24c8eb48a8c45ac768d5a2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00323-4https://doaj.org/toc/2045-2322Abstract Brain injuries substantially change the entire landscape of oscillatory dynamics and render detection of typical sleep patterns difficult. Yet, sleep is characterized not only by specific EEG waveforms, but also by its circadian organization. In the present study we investigated whether brain dynamics of patients with disorders of consciousness systematically change between day and night. We recorded ~24 h EEG at the bedside of 18 patients diagnosed to be vigilant but unaware (Unresponsive Wakefulness Syndrome) and 17 patients revealing signs of fluctuating consciousness (Minimally Conscious State). The day-to-night changes in (i) spectral power, (ii) sleep-specific oscillatory patterns and (iii) signal complexity were analyzed and compared to 26 healthy control subjects. Surprisingly, the prevalence of sleep spindles and slow waves did not systematically vary between day and night in patients, whereas day-night changes in EEG power spectra and signal complexity were revealed in minimally conscious but not unaware patients.Malgorzata WislowskaRenata del GiudiceJulia LechingerTomasz WielekDominik P. J. HeibAlain PitiotGerald PichlerGabriele MichitschJohann DonisManuel SchabusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Malgorzata Wislowska Renata del Giudice Julia Lechinger Tomasz Wielek Dominik P. J. Heib Alain Pitiot Gerald Pichler Gabriele Michitsch Johann Donis Manuel Schabus Night and day variations of sleep in patients with disorders of consciousness
description	Abstract Brain injuries substantially change the entire landscape of oscillatory dynamics and render detection of typical sleep patterns difficult. Yet, sleep is characterized not only by specific EEG waveforms, but also by its circadian organization. In the present study we investigated whether brain dynamics of patients with disorders of consciousness systematically change between day and night. We recorded ~24 h EEG at the bedside of 18 patients diagnosed to be vigilant but unaware (Unresponsive Wakefulness Syndrome) and 17 patients revealing signs of fluctuating consciousness (Minimally Conscious State). The day-to-night changes in (i) spectral power, (ii) sleep-specific oscillatory patterns and (iii) signal complexity were analyzed and compared to 26 healthy control subjects. Surprisingly, the prevalence of sleep spindles and slow waves did not systematically vary between day and night in patients, whereas day-night changes in EEG power spectra and signal complexity were revealed in minimally conscious but not unaware patients.
format	article
author	Malgorzata Wislowska Renata del Giudice Julia Lechinger Tomasz Wielek Dominik P. J. Heib Alain Pitiot Gerald Pichler Gabriele Michitsch Johann Donis Manuel Schabus
author_facet	Malgorzata Wislowska Renata del Giudice Julia Lechinger Tomasz Wielek Dominik P. J. Heib Alain Pitiot Gerald Pichler Gabriele Michitsch Johann Donis Manuel Schabus
author_sort	Malgorzata Wislowska
title	Night and day variations of sleep in patients with disorders of consciousness
title_short	Night and day variations of sleep in patients with disorders of consciousness
title_full	Night and day variations of sleep in patients with disorders of consciousness
title_fullStr	Night and day variations of sleep in patients with disorders of consciousness
title_full_unstemmed	Night and day variations of sleep in patients with disorders of consciousness
title_sort	night and day variations of sleep in patients with disorders of consciousness
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2dfdc18ab8c24c8eb48a8c45ac768d5a
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Night and day variations of sleep in patients with disorders of consciousness

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