Enterovirus particles expel capsid pentamers to enable genome release

Enterovirus particles expel capsid pentamers to enable genome release

Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120 Å for genome release.

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Autores principales: David Buchta, Tibor Füzik, Dominik Hrebík, Yevgen Levdansky, Lukáš Sukeník, Liya Mukhamedova, Jana Moravcová, Robert Vácha, Pavel Plevka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2dfed097c8834689b127851bd87cfefd
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spelling oai:doaj.org-article:2dfed097c8834689b127851bd87cfefd2021-12-02T14:38:41ZEnterovirus particles expel capsid pentamers to enable genome release10.1038/s41467-019-09132-x2041-1723https://doaj.org/article/2dfed097c8834689b127851bd87cfefd2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09132-xhttps://doaj.org/toc/2041-1723Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120 Å for genome release.David BuchtaTibor FüzikDominik HrebíkYevgen LevdanskyLukáš SukeníkLiya MukhamedovaJana MoravcováRobert VáchaPavel PlevkaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
David Buchta
Tibor Füzik
Dominik Hrebík
Yevgen Levdansky
Lukáš Sukeník
Liya Mukhamedova
Jana Moravcová
Robert Vácha
Pavel Plevka
Enterovirus particles expel capsid pentamers to enable genome release
description Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120 Å for genome release.
format article
author David Buchta
Tibor Füzik
Dominik Hrebík
Yevgen Levdansky
Lukáš Sukeník
Liya Mukhamedova
Jana Moravcová
Robert Vácha
Pavel Plevka
author_facet David Buchta
Tibor Füzik
Dominik Hrebík
Yevgen Levdansky
Lukáš Sukeník
Liya Mukhamedova
Jana Moravcová
Robert Vácha
Pavel Plevka
author_sort David Buchta
title Enterovirus particles expel capsid pentamers to enable genome release
title_short Enterovirus particles expel capsid pentamers to enable genome release
title_full Enterovirus particles expel capsid pentamers to enable genome release
title_fullStr Enterovirus particles expel capsid pentamers to enable genome release
title_full_unstemmed Enterovirus particles expel capsid pentamers to enable genome release
title_sort enterovirus particles expel capsid pentamers to enable genome release
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2dfed097c8834689b127851bd87cfefd
work_keys_str_mv AT davidbuchta enterovirusparticlesexpelcapsidpentamerstoenablegenomerelease
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AT dominikhrebik enterovirusparticlesexpelcapsidpentamerstoenablegenomerelease
AT yevgenlevdansky enterovirusparticlesexpelcapsidpentamerstoenablegenomerelease
AT lukassukenik enterovirusparticlesexpelcapsidpentamerstoenablegenomerelease
AT liyamukhamedova enterovirusparticlesexpelcapsidpentamerstoenablegenomerelease
AT janamoravcova enterovirusparticlesexpelcapsidpentamerstoenablegenomerelease
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AT pavelplevka enterovirusparticlesexpelcapsidpentamerstoenablegenomerelease
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