Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease

Liheng Chen,1 Jiawei Sun,2,3 Qiaohong Wang,1 Lingzhen Hu,1 Yi Zhang,1 Huibin Ma,2,3 Xize Jia,4,5 Xuyan Yang1 1Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, People’s Republic of China; 2School of Information and Electroni...

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Autores principales:	Chen L, Sun J, Wang Q, Hu L, Zhang Y, Ma H, Jia X, Yang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	systemic lupus erythematosus non-neuropsychiatric systemic lupus erythematosus dynamic fractional amplitude of low-frequency fluctuations dynamic regional homogeneity frequency bands resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2dffb61ad1264b378636832ab44dd73f
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record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic lupus erythematosus non-neuropsychiatric systemic lupus erythematosus dynamic fractional amplitude of low-frequency fluctuations dynamic regional homogeneity frequency bands resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	systemic lupus erythematosus non-neuropsychiatric systemic lupus erythematosus dynamic fractional amplitude of low-frequency fluctuations dynamic regional homogeneity frequency bands resting-state functional magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen L Sun J Wang Q Hu L Zhang Y Ma H Jia X Yang X Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease
description	Liheng Chen,1 Jiawei Sun,2,3 Qiaohong Wang,1 Lingzhen Hu,1 Yi Zhang,1 Huibin Ma,2,3 Xize Jia,4,5 Xuyan Yang1 1Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, People’s Republic of China; 2School of Information and Electronics Technology, Jiamusi University, Jiamusi, People’s Republic of China; 3Integrated Medical Research School, Jiamusi University, Jiamusi, People’s Republic of China; 4Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, People’s Republic of China; 5Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, People’s Republic of ChinaCorrespondence: Xize JiaInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, People’s Republic of ChinaEmail jiaxize@hznu.edu.cnXuyan YangDepartment of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, People’s Republic of ChinaEmail hangzhouyxy@zju.edu.cnPurpose: In this study, we seek to investigate dynamic changes of brain activity in non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) patients with inactive disease.Patients and Methods: Thirty-one non-NPSLE patients with inactive disease and 20 matched healthy controls underwent the blood oxygenation level-dependent fMRI examination. Dynamic regional homogeneity (ReHo) and fractional amplitude of low-frequency ﬂuctuations (fALFF) were used to analyze the brain activity in typical band (0.01– 0.08 Hz), slow-4 (0.027– 0.073 Hz) and slow-5 (0.01– 0.027 Hz). Pearson’s correlation analysis was performed to correlate dynamic regional homogeneity (dReHo) and dynamic fractional amplitude of low-frequency ﬂuctuations (dfALFF) values for clusters of voxels where significant group differences were found with clinical variables in non-NPSLE patients with inactive disease.Results: In typical band, non-NPSLE patients showed increased dReHo in left middle occipital gyrus (MOG) compared to healthy controls. Meanwhile, patients showed decreased dfALFF in right superior frontal gyrus (SFG) and bilateral middle frontal gyrus (MFG) in typical band. In slow-4, increased dReHo in left MOG was found in non-NPSLE patients. In slow-5, non-NPSLE patients showed increased dReHo in left MOG, left calcarine fissure and surrounding cortex, right precentral gyrus (PreCG) and left postcentral gyrus (PoCG). Meanwhile, non-NPSLE patients showed decreased dfALFF in left SFG, right MFG, and right PreCG in slow-5. Moreover, the glucocorticoid dose showed significantly negative correlations with dReHo values in right PreCG in slow-5, left PoCG in slow-5, and left MOG in typical band.Conclusion: dReHo and dfALFF abnormalities in different frequency bands may be the key characteristics in the pathogenesis mechanism of non-NPSLE.Keywords: systemic lupus erythematosus, non-neuropsychiatric systemic lupus erythematosus, dynamic fractional amplitude of low-frequency fluctuations, dynamic regional homogeneity, frequency bands, resting-state functional magnetic resonance imaging
format	article
author	Chen L Sun J Wang Q Hu L Zhang Y Ma H Jia X Yang X
author_facet	Chen L Sun J Wang Q Hu L Zhang Y Ma H Jia X Yang X
author_sort	Chen L
title	Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease
title_short	Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease
title_full	Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease
title_fullStr	Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease
title_full_unstemmed	Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease
title_sort	altered temporal dynamics of brain activity in multiple-frequency bands in non-neuropsychiatric systemic lupus erythematosus patients with inactive disease
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2dffb61ad1264b378636832ab44dd73f
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spelling	oai:doaj.org-article:2dffb61ad1264b378636832ab44dd73f2021-12-02T14:49:49ZAltered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease1178-2021https://doaj.org/article/2dffb61ad1264b378636832ab44dd73f2021-05-01T00:00:00Zhttps://www.dovepress.com/altered-temporal-dynamics-of-brain-activity-in-multiple-frequency-band-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Liheng Chen,1 Jiawei Sun,2,3 Qiaohong Wang,1 Lingzhen Hu,1 Yi Zhang,1 Huibin Ma,2,3 Xize Jia,4,5 Xuyan Yang1 1Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, People’s Republic of China; 2School of Information and Electronics Technology, Jiamusi University, Jiamusi, People’s Republic of China; 3Integrated Medical Research School, Jiamusi University, Jiamusi, People’s Republic of China; 4Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, People’s Republic of China; 5Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, People’s Republic of ChinaCorrespondence: Xize JiaInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, People’s Republic of ChinaEmail jiaxize@hznu.edu.cnXuyan YangDepartment of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, People’s Republic of ChinaEmail hangzhouyxy@zju.edu.cnPurpose: In this study, we seek to investigate dynamic changes of brain activity in non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) patients with inactive disease.Patients and Methods: Thirty-one non-NPSLE patients with inactive disease and 20 matched healthy controls underwent the blood oxygenation level-dependent fMRI examination. Dynamic regional homogeneity (ReHo) and fractional amplitude of low-frequency ﬂuctuations (fALFF) were used to analyze the brain activity in typical band (0.01– 0.08 Hz), slow-4 (0.027– 0.073 Hz) and slow-5 (0.01– 0.027 Hz). Pearson’s correlation analysis was performed to correlate dynamic regional homogeneity (dReHo) and dynamic fractional amplitude of low-frequency ﬂuctuations (dfALFF) values for clusters of voxels where significant group differences were found with clinical variables in non-NPSLE patients with inactive disease.Results: In typical band, non-NPSLE patients showed increased dReHo in left middle occipital gyrus (MOG) compared to healthy controls. Meanwhile, patients showed decreased dfALFF in right superior frontal gyrus (SFG) and bilateral middle frontal gyrus (MFG) in typical band. In slow-4, increased dReHo in left MOG was found in non-NPSLE patients. In slow-5, non-NPSLE patients showed increased dReHo in left MOG, left calcarine fissure and surrounding cortex, right precentral gyrus (PreCG) and left postcentral gyrus (PoCG). Meanwhile, non-NPSLE patients showed decreased dfALFF in left SFG, right MFG, and right PreCG in slow-5. Moreover, the glucocorticoid dose showed significantly negative correlations with dReHo values in right PreCG in slow-5, left PoCG in slow-5, and left MOG in typical band.Conclusion: dReHo and dfALFF abnormalities in different frequency bands may be the key characteristics in the pathogenesis mechanism of non-NPSLE.Keywords: systemic lupus erythematosus, non-neuropsychiatric systemic lupus erythematosus, dynamic fractional amplitude of low-frequency fluctuations, dynamic regional homogeneity, frequency bands, resting-state functional magnetic resonance imagingChen LSun JWang QHu LZhang YMa HJia XYang XDove Medical Pressarticlesystemic lupus erythematosusnon-neuropsychiatric systemic lupus erythematosusdynamic fractional amplitude of low-frequency fluctuationsdynamic regional homogeneityfrequency bandsresting-state functional magnetic resonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1385-1395 (2021)

Altered Temporal Dynamics of Brain Activity in Multiple-Frequency Bands in Non-Neuropsychiatric Systemic Lupus Erythematosus Patients with Inactive Disease

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