Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

Progressive tubule cell damage results in defects in mitochondrial metabolism and exercise seems to be beneficial during chronic kidney disease. Here Peng et al. show that irisin, an exercise-induced myokine, improves kidney energy metabolism by inhibiting TGF-β type 1 receptors and ameliorates fibr...

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Autores principales:	Hui Peng, Qianqian Wang, Tanqi Lou, Jun Qin, Sungyun Jung, Vivekananda Shetty, Feng Li, Yanlin Wang, Xin-hua Feng, William E. Mitch, Brett H. Graham, Zhaoyong Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e02db7b780c4d058faf0b3bda3f1292
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spelling	oai:doaj.org-article:2e02db7b780c4d058faf0b3bda3f12922021-12-02T14:42:08ZMyokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys10.1038/s41467-017-01646-62041-1723https://doaj.org/article/2e02db7b780c4d058faf0b3bda3f12922017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01646-6https://doaj.org/toc/2041-1723Progressive tubule cell damage results in defects in mitochondrial metabolism and exercise seems to be beneficial during chronic kidney disease. Here Peng et al. show that irisin, an exercise-induced myokine, improves kidney energy metabolism by inhibiting TGF-β type 1 receptors and ameliorates fibrosis.Hui PengQianqian WangTanqi LouJun QinSungyun JungVivekananda ShettyFeng LiYanlin WangXin-hua FengWilliam E. MitchBrett H. GrahamZhaoyong HuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui Peng Qianqian Wang Tanqi Lou Jun Qin Sungyun Jung Vivekananda Shetty Feng Li Yanlin Wang Xin-hua Feng William E. Mitch Brett H. Graham Zhaoyong Hu Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
description	Progressive tubule cell damage results in defects in mitochondrial metabolism and exercise seems to be beneficial during chronic kidney disease. Here Peng et al. show that irisin, an exercise-induced myokine, improves kidney energy metabolism by inhibiting TGF-β type 1 receptors and ameliorates fibrosis.
format	article
author	Hui Peng Qianqian Wang Tanqi Lou Jun Qin Sungyun Jung Vivekananda Shetty Feng Li Yanlin Wang Xin-hua Feng William E. Mitch Brett H. Graham Zhaoyong Hu
author_facet	Hui Peng Qianqian Wang Tanqi Lou Jun Qin Sungyun Jung Vivekananda Shetty Feng Li Yanlin Wang Xin-hua Feng William E. Mitch Brett H. Graham Zhaoyong Hu
author_sort	Hui Peng
title	Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
title_short	Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
title_full	Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
title_fullStr	Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
title_full_unstemmed	Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
title_sort	myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2e02db7b780c4d058faf0b3bda3f1292
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Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

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