Feedback from retinal ganglion cells to the inner retina.

Retinal ganglion cells (RGCs) are thought to be strictly postsynaptic within the retina. They carry visual signals from the eye to the brain, but do not make chemical synapses onto other retinal neurons. Nevertheless, they form gap junctions with other RGCs and amacrine cells, providing possibilitie...

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Autores principales:	Anastasiia Vlasiuk, Hiroki Asari
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e02defda8c24d40a35f6a9b3699acf2
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spelling	oai:doaj.org-article:2e02defda8c24d40a35f6a9b3699acf22021-12-02T20:06:37ZFeedback from retinal ganglion cells to the inner retina.1932-620310.1371/journal.pone.0254611https://doaj.org/article/2e02defda8c24d40a35f6a9b3699acf22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254611https://doaj.org/toc/1932-6203Retinal ganglion cells (RGCs) are thought to be strictly postsynaptic within the retina. They carry visual signals from the eye to the brain, but do not make chemical synapses onto other retinal neurons. Nevertheless, they form gap junctions with other RGCs and amacrine cells, providing possibilities for RGC signals to feed back into the inner retina. Here we identified such feedback circuitry in the salamander and mouse retinas. First, using biologically inspired circuit models, we found mutual inhibition among RGCs of the same type. We then experimentally determined that this effect is mediated by gap junctions with amacrine cells. Finally, we found that this negative feedback lowers RGC visual response gain without affecting feature selectivity. The principal neurons of the retina therefore participate in a recurrent circuit much as those in other brain areas, not being a mere collector of retinal signals, but are actively involved in visual computations.Anastasiia VlasiukHiroki AsariPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254611 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anastasiia Vlasiuk Hiroki Asari Feedback from retinal ganglion cells to the inner retina.
description	Retinal ganglion cells (RGCs) are thought to be strictly postsynaptic within the retina. They carry visual signals from the eye to the brain, but do not make chemical synapses onto other retinal neurons. Nevertheless, they form gap junctions with other RGCs and amacrine cells, providing possibilities for RGC signals to feed back into the inner retina. Here we identified such feedback circuitry in the salamander and mouse retinas. First, using biologically inspired circuit models, we found mutual inhibition among RGCs of the same type. We then experimentally determined that this effect is mediated by gap junctions with amacrine cells. Finally, we found that this negative feedback lowers RGC visual response gain without affecting feature selectivity. The principal neurons of the retina therefore participate in a recurrent circuit much as those in other brain areas, not being a mere collector of retinal signals, but are actively involved in visual computations.
format	article
author	Anastasiia Vlasiuk Hiroki Asari
author_facet	Anastasiia Vlasiuk Hiroki Asari
author_sort	Anastasiia Vlasiuk
title	Feedback from retinal ganglion cells to the inner retina.
title_short	Feedback from retinal ganglion cells to the inner retina.
title_full	Feedback from retinal ganglion cells to the inner retina.
title_fullStr	Feedback from retinal ganglion cells to the inner retina.
title_full_unstemmed	Feedback from retinal ganglion cells to the inner retina.
title_sort	feedback from retinal ganglion cells to the inner retina.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2e02defda8c24d40a35f6a9b3699acf2
work_keys_str_mv	AT anastasiiavlasiuk feedbackfromretinalganglioncellstotheinnerretina AT hirokiasari feedbackfromretinalganglioncellstotheinnerretina
_version_	1718375352599838720

Feedback from retinal ganglion cells to the inner retina.

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