Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes

Abstract We examined the associations of gestational diabetes mellitus (GDM) and women’s weight status from pre-pregnancy through post-delivery with the risk of developing dysglycaemia [impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes (T2D)] 4–6 years post-delivery. Using Po...

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Autores principales:	Ling-Wei Chen, Shu E Soh, Mya-Thway Tint, See Ling Loy, Fabian Yap, Kok Hian Tan, Yung Seng Lee, Lynette Pei-Chi Shek, Keith M. Godfrey, Peter D. Gluckman, Johan G. Eriksson, Yap-Seng Chong, Shiao-Yng Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e0516f1860241e7ac5656cec250b8cd
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spelling	oai:doaj.org-article:2e0516f1860241e7ac5656cec250b8cd2021-12-02T13:34:32ZCombined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes10.1038/s41598-021-82789-x2045-2322https://doaj.org/article/2e0516f1860241e7ac5656cec250b8cd2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82789-xhttps://doaj.org/toc/2045-2322Abstract We examined the associations of gestational diabetes mellitus (GDM) and women’s weight status from pre-pregnancy through post-delivery with the risk of developing dysglycaemia [impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes (T2D)] 4–6 years post-delivery. Using Poisson regression with confounder adjustments, we assessed associations of standard categorisations of prospectively ascertained pre-pregnancy overweight and obesity (OWOB), gestational weight gain (GWG) and substantial post-delivery weight retention (PDWR) with post-delivery dysglycaemia (n = 692). Women with GDM had a higher risk of later T2D [relative risk (95% CI) 12.07 (4.55, 32.02)] and dysglycaemia [3.02 (2.19, 4.16)] compared with non-GDM women. Independent of GDM, women with pre-pregnancy OWOB also had a higher risk of post-delivery dysglycaemia. Women with GDM who were OWOB pre-pregnancy and had subsequent PDWR (≥ 5 kg) had 2.38 times (1.29, 4.41) the risk of post-delivery dysglycaemia compared with pre-pregnancy lean GDM women without PDWR. No consistent associations were observed between GWG and later dysglycaemia risk. In conclusion, women with GDM have a higher risk of T2D 4–6 years after the index pregnancy. Pre-pregnancy OWOB and PDWR exacerbate the risk of post-delivery dysglycaemia. Weight management during preconception and post-delivery represent early windows of opportunity for improving long-term health, especially in those with GDM.Ling-Wei ChenShu E SohMya-Thway TintSee Ling LoyFabian YapKok Hian TanYung Seng LeeLynette Pei-Chi ShekKeith M. GodfreyPeter D. GluckmanJohan G. ErikssonYap-Seng ChongShiao-Yng ChanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ling-Wei Chen Shu E Soh Mya-Thway Tint See Ling Loy Fabian Yap Kok Hian Tan Yung Seng Lee Lynette Pei-Chi Shek Keith M. Godfrey Peter D. Gluckman Johan G. Eriksson Yap-Seng Chong Shiao-Yng Chan Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
description	Abstract We examined the associations of gestational diabetes mellitus (GDM) and women’s weight status from pre-pregnancy through post-delivery with the risk of developing dysglycaemia [impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes (T2D)] 4–6 years post-delivery. Using Poisson regression with confounder adjustments, we assessed associations of standard categorisations of prospectively ascertained pre-pregnancy overweight and obesity (OWOB), gestational weight gain (GWG) and substantial post-delivery weight retention (PDWR) with post-delivery dysglycaemia (n = 692). Women with GDM had a higher risk of later T2D [relative risk (95% CI) 12.07 (4.55, 32.02)] and dysglycaemia [3.02 (2.19, 4.16)] compared with non-GDM women. Independent of GDM, women with pre-pregnancy OWOB also had a higher risk of post-delivery dysglycaemia. Women with GDM who were OWOB pre-pregnancy and had subsequent PDWR (≥ 5 kg) had 2.38 times (1.29, 4.41) the risk of post-delivery dysglycaemia compared with pre-pregnancy lean GDM women without PDWR. No consistent associations were observed between GWG and later dysglycaemia risk. In conclusion, women with GDM have a higher risk of T2D 4–6 years after the index pregnancy. Pre-pregnancy OWOB and PDWR exacerbate the risk of post-delivery dysglycaemia. Weight management during preconception and post-delivery represent early windows of opportunity for improving long-term health, especially in those with GDM.
format	article
author	Ling-Wei Chen Shu E Soh Mya-Thway Tint See Ling Loy Fabian Yap Kok Hian Tan Yung Seng Lee Lynette Pei-Chi Shek Keith M. Godfrey Peter D. Gluckman Johan G. Eriksson Yap-Seng Chong Shiao-Yng Chan
author_facet	Ling-Wei Chen Shu E Soh Mya-Thway Tint See Ling Loy Fabian Yap Kok Hian Tan Yung Seng Lee Lynette Pei-Chi Shek Keith M. Godfrey Peter D. Gluckman Johan G. Eriksson Yap-Seng Chong Shiao-Yng Chan
author_sort	Ling-Wei Chen
title	Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
title_short	Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
title_full	Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
title_fullStr	Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
title_full_unstemmed	Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
title_sort	combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e0516f1860241e7ac5656cec250b8cd
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Combined analysis of gestational diabetes and maternal weight status from pre-pregnancy through post-delivery in future development of type 2 diabetes

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