Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice

Abstract Several cytokines have been reported to participate in spermatogenesis, including interleukin-6 (IL6). However, not many studies have been conducted on the loss of Il6 on the male reproductive tract. Nonetheless, there is considerable knowledge regarding the pathological and physiological r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thaís Alves-Silva, Geanne Arantes Freitas, Talita Guerreiro Rodrigues Húngaro, Adriano Cleis Arruda, Lila Missae Oyama, Maria Christina Werneck Avellar, Ronaldo Carvalho Araujo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e07bb587dc44579b3374b3d523803ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2e07bb587dc44579b3374b3d523803ca
record_format	dspace
spelling	oai:doaj.org-article:2e07bb587dc44579b3374b3d523803ca2021-12-02T15:02:40ZInterleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice10.1038/s41598-021-90872-62045-2322https://doaj.org/article/2e07bb587dc44579b3374b3d523803ca2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90872-6https://doaj.org/toc/2045-2322Abstract Several cytokines have been reported to participate in spermatogenesis, including interleukin-6 (IL6). However, not many studies have been conducted on the loss of Il6 on the male reproductive tract. Nonetheless, there is considerable knowledge regarding the pathological and physiological role of IL6 on spermatogenesis. In this way, this study evaluated the impact of Il6 deficiency on mice testicles in the absence of infection or inflammation. We showed that Il6 deficiency increases daily sperm production, the number of spermatids, and the testicular testosterone and dihydrotestosterone levels. Besides that, mice with a deleted Il6 (IL6KO) showed increased testicular SOCS3 levels, with no changes in pJAK/JAK and pSTAT3/STAT3 ratios. It is worth noting that the aforementioned pathway is not the only pathway to up-regulate SOCS3, nor is it the only SOCS3 target, thus proposing that the increase of SOCS3 in the testis occurs independently of the JAK-STAT signaling in IL6KO mice. Therefore, we suggest that the lack of Il6 drives androgenic production by increasing SOCS3 in the testis, thus leading to an increase in spermatogenesis.Thaís Alves-SilvaGeanne Arantes FreitasTalita Guerreiro Rodrigues HúngaroAdriano Cleis ArrudaLila Missae OyamaMaria Christina Werneck AvellarRonaldo Carvalho AraujoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thaís Alves-Silva Geanne Arantes Freitas Talita Guerreiro Rodrigues Húngaro Adriano Cleis Arruda Lila Missae Oyama Maria Christina Werneck Avellar Ronaldo Carvalho Araujo Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice
description	Abstract Several cytokines have been reported to participate in spermatogenesis, including interleukin-6 (IL6). However, not many studies have been conducted on the loss of Il6 on the male reproductive tract. Nonetheless, there is considerable knowledge regarding the pathological and physiological role of IL6 on spermatogenesis. In this way, this study evaluated the impact of Il6 deficiency on mice testicles in the absence of infection or inflammation. We showed that Il6 deficiency increases daily sperm production, the number of spermatids, and the testicular testosterone and dihydrotestosterone levels. Besides that, mice with a deleted Il6 (IL6KO) showed increased testicular SOCS3 levels, with no changes in pJAK/JAK and pSTAT3/STAT3 ratios. It is worth noting that the aforementioned pathway is not the only pathway to up-regulate SOCS3, nor is it the only SOCS3 target, thus proposing that the increase of SOCS3 in the testis occurs independently of the JAK-STAT signaling in IL6KO mice. Therefore, we suggest that the lack of Il6 drives androgenic production by increasing SOCS3 in the testis, thus leading to an increase in spermatogenesis.
format	article
author	Thaís Alves-Silva Geanne Arantes Freitas Talita Guerreiro Rodrigues Húngaro Adriano Cleis Arruda Lila Missae Oyama Maria Christina Werneck Avellar Ronaldo Carvalho Araujo
author_facet	Thaís Alves-Silva Geanne Arantes Freitas Talita Guerreiro Rodrigues Húngaro Adriano Cleis Arruda Lila Missae Oyama Maria Christina Werneck Avellar Ronaldo Carvalho Araujo
author_sort	Thaís Alves-Silva
title	Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice
title_short	Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice
title_full	Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice
title_fullStr	Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice
title_full_unstemmed	Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice
title_sort	interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (socs3) in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e07bb587dc44579b3374b3d523803ca
work_keys_str_mv	AT thaisalvessilva interleukin6deficiencymodulatestesticularfunctionbyincreasingtheexpressionofsuppressorofcytokinesignaling3socs3inmice AT geannearantesfreitas interleukin6deficiencymodulatestesticularfunctionbyincreasingtheexpressionofsuppressorofcytokinesignaling3socs3inmice AT talitaguerreirorodrigueshungaro interleukin6deficiencymodulatestesticularfunctionbyincreasingtheexpressionofsuppressorofcytokinesignaling3socs3inmice AT adrianocleisarruda interleukin6deficiencymodulatestesticularfunctionbyincreasingtheexpressionofsuppressorofcytokinesignaling3socs3inmice AT lilamissaeoyama interleukin6deficiencymodulatestesticularfunctionbyincreasingtheexpressionofsuppressorofcytokinesignaling3socs3inmice AT mariachristinawerneckavellar interleukin6deficiencymodulatestesticularfunctionbyincreasingtheexpressionofsuppressorofcytokinesignaling3socs3inmice AT ronaldocarvalhoaraujo interleukin6deficiencymodulatestesticularfunctionbyincreasingtheexpressionofsuppressorofcytokinesignaling3socs3inmice
_version_	1718389068510789632

Interleukin-6 deficiency modulates testicular function by increasing the expression of suppressor of cytokine signaling 3 (SOCS3) in mice

Ejemplares similares