Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay

The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clust...

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Auteurs principaux:	Menuka Karki, Neda Keyhaninejad, Charles B. Shuster
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2e0996f0790f44e394e9f142b8319d0d
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spelling	oai:doaj.org-article:2e0996f0790f44e394e9f142b8319d0d2021-12-02T15:38:51ZPrecocious centriole disengagement and centrosome fragmentation induced by mitotic delay10.1038/ncomms158032041-1723https://doaj.org/article/2e0996f0790f44e394e9f142b8319d0d2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15803https://doaj.org/toc/2041-1723The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clustering.Menuka KarkiNeda KeyhaninejadCharles B. ShusterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Menuka Karki Neda Keyhaninejad Charles B. Shuster Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
description	The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clustering.
format	article
author	Menuka Karki Neda Keyhaninejad Charles B. Shuster
author_facet	Menuka Karki Neda Keyhaninejad Charles B. Shuster
author_sort	Menuka Karki
title	Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
title_short	Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
title_full	Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
title_fullStr	Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
title_full_unstemmed	Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
title_sort	precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2e0996f0790f44e394e9f142b8319d0d
work_keys_str_mv	AT menukakarki precociouscentrioledisengagementandcentrosomefragmentationinducedbymitoticdelay AT nedakeyhaninejad precociouscentrioledisengagementandcentrosomefragmentationinducedbymitoticdelay AT charlesbshuster precociouscentrioledisengagementandcentrosomefragmentationinducedbymitoticdelay
_version_	1718386040614420480

Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay

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