Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay

The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clust...

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Bibliographic Details
Main Authors: Menuka Karki, Neda Keyhaninejad, Charles B. Shuster
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/2e0996f0790f44e394e9f142b8319d0d
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