In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review

Retinitis pigmentosa (RP) is the most recognized inherited retinal disorder involving progressive photoreceptors degeneration which eventually causes blindness. However, the pathogenesis of RP is still unclear, making it difficult to establish satisfying treatments. Evidence have been found to suppo...

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Autores principales:	Bing-Wen Lu, Guo-Jun Chao, Gai-Ping Wu, Li-Ke Xie
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	retinitis pigmentosa optical coherence tomography angiography vascular dysfunction microglia activation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2e0c319644c64921b115829f4cbe71ea
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spelling	oai:doaj.org-article:2e0c319644c64921b115829f4cbe71ea2021-11-26T04:02:12ZIn depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review2222-39592227-489810.18240/ijo.2021.12.25https://doaj.org/article/2e0c319644c64921b115829f4cbe71ea2021-12-01T00:00:00Zhttp://ies.ijo.cn/en_publish/2021/12/20211225.pdfhttps://doaj.org/toc/2222-3959https://doaj.org/toc/2227-4898Retinitis pigmentosa (RP) is the most recognized inherited retinal disorder involving progressive photoreceptors degeneration which eventually causes blindness. However, the pathogenesis of RP is still unclear, making it difficult to establish satisfying treatments. Evidence have been found to support the theory that vascular dysfunction is associated with the progression of RP. Optical coherence tomography angiography (OCTA) is a newly developed technology that enables visualization as well as quantitative assessment of retinal and choroidal vasculature non-invasively. Advances in OCTA have opened a window for in-depth understanding of RP pathogenesis. Here, we propose a hypothesis of RP pathogenesis based on the current OCTA findings in RP, which includes four stages and two important key factors, vascular dysfunction and microglia activation. Further, we discuss the future animal experiments needed and how advanced OCTA technology can help to further verity the hypothesis. The final goal is to explore potential treatment options with enhanced understanding of RP pathogenesis.Bing-Wen LuGuo-Jun ChaoGai-Ping WuLi-Ke XiePress of International Journal of Ophthalmology (IJO PRESS)articleretinitis pigmentosaoptical coherence tomography angiographyvascular dysfunctionmicroglia activationOphthalmologyRE1-994ENInternational Journal of Ophthalmology, Vol 14, Iss 12, Pp 1979-1985 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinitis pigmentosa optical coherence tomography angiography vascular dysfunction microglia activation Ophthalmology RE1-994
spellingShingle	retinitis pigmentosa optical coherence tomography angiography vascular dysfunction microglia activation Ophthalmology RE1-994 Bing-Wen Lu Guo-Jun Chao Gai-Ping Wu Li-Ke Xie In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
description	Retinitis pigmentosa (RP) is the most recognized inherited retinal disorder involving progressive photoreceptors degeneration which eventually causes blindness. However, the pathogenesis of RP is still unclear, making it difficult to establish satisfying treatments. Evidence have been found to support the theory that vascular dysfunction is associated with the progression of RP. Optical coherence tomography angiography (OCTA) is a newly developed technology that enables visualization as well as quantitative assessment of retinal and choroidal vasculature non-invasively. Advances in OCTA have opened a window for in-depth understanding of RP pathogenesis. Here, we propose a hypothesis of RP pathogenesis based on the current OCTA findings in RP, which includes four stages and two important key factors, vascular dysfunction and microglia activation. Further, we discuss the future animal experiments needed and how advanced OCTA technology can help to further verity the hypothesis. The final goal is to explore potential treatment options with enhanced understanding of RP pathogenesis.
format	article
author	Bing-Wen Lu Guo-Jun Chao Gai-Ping Wu Li-Ke Xie
author_facet	Bing-Wen Lu Guo-Jun Chao Gai-Ping Wu Li-Ke Xie
author_sort	Bing-Wen Lu
title	In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
title_short	In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
title_full	In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
title_fullStr	In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
title_full_unstemmed	In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
title_sort	in depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/2e0c319644c64921b115829f4cbe71ea
work_keys_str_mv	AT bingwenlu indepthunderstandingofretinitispigmentosapathogenesisthroughopticalcoherencetomographyangiographyanalysisanarrativereview AT guojunchao indepthunderstandingofretinitispigmentosapathogenesisthroughopticalcoherencetomographyangiographyanalysisanarrativereview AT gaipingwu indepthunderstandingofretinitispigmentosapathogenesisthroughopticalcoherencetomographyangiographyanalysisanarrativereview AT likexie indepthunderstandingofretinitispigmentosapathogenesisthroughopticalcoherencetomographyangiographyanalysisanarrativereview
_version_	1718409891383607296

In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis: a narrative review

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