Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer

Jiaxing Yang,1 Yongliang Teng,2 Yu Fu,3 Chunyu Zhang31Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republi...

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Autores principales:	Yang J, Teng Y, Fu Y, Zhang C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	cell membrane silica nanoparticles chlorins e6 photodynamic therapy gastric cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2e0c4a7255c347f0b40fda90dc8f55fb
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spelling	oai:doaj.org-article:2e0c4a7255c347f0b40fda90dc8f55fb2021-12-02T01:05:05ZChlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer1178-2013https://doaj.org/article/2e0c4a7255c347f0b40fda90dc8f55fb2019-07-01T00:00:00Zhttps://www.dovepress.com/chlorins-e6-loaded-silica-nanoparticles-coated-with-gastric-cancer-cel-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jiaxing Yang,1 Yongliang Teng,2 Yu Fu,3 Chunyu Zhang31Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 3Department of Radiology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaBackground: Photodynamic therapy (PDT) is widely recognized as a promising way to cure cancer. However, the limited tumor homing property of currently available drug delivery systems (DDSs) is the bottleneck for the delivery of photodynamic agents.Purpose: In our study, we decorated silica nanoparticles (SLN) with cell membrane (CM) derived from SGC7901 cells to construct carrier (CM/SLN) which was able to to specifically target the homogenous SGC7901 cells.Materials and methods: Furthermore, the decent drug loading capability of CM/SLN was adopted to load photodynamic agent chlorins e6 (Ce6) to finally construct aDDS suitable for tumor-targeted PDT of gastric cancer.Results: The experimental results suggested that CM/SLN/Ce6 was nano-sized particles with good dispersion and stability in physiological conditions. Moreover, due to the modification of CM,CM/SLN/Ce6 could specifically target the homogenous SGC7901 cells both in vitro and in vivo. Most importantly, further in vivo results demonstrated that the CM/SLN/Ce6 showed a better anticancer outcome compared to SLN/Ce6.Conclusion: CM/SLN/Ce6 might be a promising platform for effective tumor targeted PDT of gastric cancer.Keywords: cell membrane, silica nanoparticles, chlorins e6, photodynamic therapy, gastric cancerYang JTeng YFu YZhang CDove Medical Pressarticlecell membranesilica nanoparticleschlorins e6photodynamic therapygastric cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5061-5071 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell membrane silica nanoparticles chlorins e6 photodynamic therapy gastric cancer Medicine (General) R5-920
spellingShingle	cell membrane silica nanoparticles chlorins e6 photodynamic therapy gastric cancer Medicine (General) R5-920 Yang J Teng Y Fu Y Zhang C Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer
description	Jiaxing Yang,1 Yongliang Teng,2 Yu Fu,3 Chunyu Zhang31Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 3Department of Radiology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaBackground: Photodynamic therapy (PDT) is widely recognized as a promising way to cure cancer. However, the limited tumor homing property of currently available drug delivery systems (DDSs) is the bottleneck for the delivery of photodynamic agents.Purpose: In our study, we decorated silica nanoparticles (SLN) with cell membrane (CM) derived from SGC7901 cells to construct carrier (CM/SLN) which was able to to specifically target the homogenous SGC7901 cells.Materials and methods: Furthermore, the decent drug loading capability of CM/SLN was adopted to load photodynamic agent chlorins e6 (Ce6) to finally construct aDDS suitable for tumor-targeted PDT of gastric cancer.Results: The experimental results suggested that CM/SLN/Ce6 was nano-sized particles with good dispersion and stability in physiological conditions. Moreover, due to the modification of CM,CM/SLN/Ce6 could specifically target the homogenous SGC7901 cells both in vitro and in vivo. Most importantly, further in vivo results demonstrated that the CM/SLN/Ce6 showed a better anticancer outcome compared to SLN/Ce6.Conclusion: CM/SLN/Ce6 might be a promising platform for effective tumor targeted PDT of gastric cancer.Keywords: cell membrane, silica nanoparticles, chlorins e6, photodynamic therapy, gastric cancer
format	article
author	Yang J Teng Y Fu Y Zhang C
author_facet	Yang J Teng Y Fu Y Zhang C
author_sort	Yang J
title	Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer
title_short	Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer
title_full	Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer
title_fullStr	Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer
title_full_unstemmed	Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer
title_sort	chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2e0c4a7255c347f0b40fda90dc8f55fb
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_version_	1718403306338910208

Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer

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