Nanopore sensors for viral particle quantification: current progress and future prospects

Rapid, inexpensive, and laboratory-free diagnostic of viral pathogens is highly critical in controlling viral pandemics. In recent years, nanopore-based sensors have been employed to detect, identify, and classify virus particles. By tracing ionic current containing target molecules across nano-scal...

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Autores principales:	Shiva Akhtarian, Saba Miri, Ali Doostmohammadi, Satinder Kaur Brar, Pouya Rezai
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	nanopore sensor virus detection virus classification microfluidics biosensors artificial intelligence resistive pulse sensing Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/2e0c685fa3be4d2b999b5df17562dae7
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spelling	oai:doaj.org-article:2e0c685fa3be4d2b999b5df17562dae72021-11-26T11:19:49ZNanopore sensors for viral particle quantification: current progress and future prospects2165-59792165-598710.1080/21655979.2021.1995991https://doaj.org/article/2e0c685fa3be4d2b999b5df17562dae72021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1995991https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Rapid, inexpensive, and laboratory-free diagnostic of viral pathogens is highly critical in controlling viral pandemics. In recent years, nanopore-based sensors have been employed to detect, identify, and classify virus particles. By tracing ionic current containing target molecules across nano-scale pores, nanopore sensors can recognize the target molecules at the single-molecule level. In the case of viruses, they enable discrimination of individual viruses and obtaining important information on the physical and chemical properties of viral particles. Despite classical benchtop virus detection methods, such as amplification techniques (e.g., PCR) or immunological assays (e.g., ELISA), that are mainly laboratory-based, expensive and time-consuming, nanopore-based sensing methods can enable low-cost and real-time point-of-care (PoC) and point-of-need (PoN) monitoring of target viruses. This review discusses the limitations of classical virus detection methods in PoN virus monitoring and then provides a comprehensive overview of nanopore sensing technology and its emerging applications in quantifying virus particles and classifying virus sub-types. Afterward, it discusses the recent progress in the field of nanopore sensing, including integrating nanopore sensors with microfabrication technology, microfluidics and artificial intelligence, which have been demonstrated to be promising in developing the next generation of low-cost and portable biosensors for the sensitive recognition of viruses and emerging pathogens.Shiva AkhtarianSaba MiriAli DoostmohammadiSatinder Kaur BrarPouya RezaiTaylor & Francis Grouparticlenanopore sensorvirus detectionvirus classificationmicrofluidicsbiosensorsartificial intelligenceresistive pulse sensingBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 2, Pp 9189-9215 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanopore sensor virus detection virus classification microfluidics biosensors artificial intelligence resistive pulse sensing Biotechnology TP248.13-248.65
spellingShingle	nanopore sensor virus detection virus classification microfluidics biosensors artificial intelligence resistive pulse sensing Biotechnology TP248.13-248.65 Shiva Akhtarian Saba Miri Ali Doostmohammadi Satinder Kaur Brar Pouya Rezai Nanopore sensors for viral particle quantification: current progress and future prospects
description	Rapid, inexpensive, and laboratory-free diagnostic of viral pathogens is highly critical in controlling viral pandemics. In recent years, nanopore-based sensors have been employed to detect, identify, and classify virus particles. By tracing ionic current containing target molecules across nano-scale pores, nanopore sensors can recognize the target molecules at the single-molecule level. In the case of viruses, they enable discrimination of individual viruses and obtaining important information on the physical and chemical properties of viral particles. Despite classical benchtop virus detection methods, such as amplification techniques (e.g., PCR) or immunological assays (e.g., ELISA), that are mainly laboratory-based, expensive and time-consuming, nanopore-based sensing methods can enable low-cost and real-time point-of-care (PoC) and point-of-need (PoN) monitoring of target viruses. This review discusses the limitations of classical virus detection methods in PoN virus monitoring and then provides a comprehensive overview of nanopore sensing technology and its emerging applications in quantifying virus particles and classifying virus sub-types. Afterward, it discusses the recent progress in the field of nanopore sensing, including integrating nanopore sensors with microfabrication technology, microfluidics and artificial intelligence, which have been demonstrated to be promising in developing the next generation of low-cost and portable biosensors for the sensitive recognition of viruses and emerging pathogens.
format	article
author	Shiva Akhtarian Saba Miri Ali Doostmohammadi Satinder Kaur Brar Pouya Rezai
author_facet	Shiva Akhtarian Saba Miri Ali Doostmohammadi Satinder Kaur Brar Pouya Rezai
author_sort	Shiva Akhtarian
title	Nanopore sensors for viral particle quantification: current progress and future prospects
title_short	Nanopore sensors for viral particle quantification: current progress and future prospects
title_full	Nanopore sensors for viral particle quantification: current progress and future prospects
title_fullStr	Nanopore sensors for viral particle quantification: current progress and future prospects
title_full_unstemmed	Nanopore sensors for viral particle quantification: current progress and future prospects
title_sort	nanopore sensors for viral particle quantification: current progress and future prospects
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/2e0c685fa3be4d2b999b5df17562dae7
work_keys_str_mv	AT shivaakhtarian nanoporesensorsforviralparticlequantificationcurrentprogressandfutureprospects AT sabamiri nanoporesensorsforviralparticlequantificationcurrentprogressandfutureprospects AT alidoostmohammadi nanoporesensorsforviralparticlequantificationcurrentprogressandfutureprospects AT satinderkaurbrar nanoporesensorsforviralparticlequantificationcurrentprogressandfutureprospects AT pouyarezai nanoporesensorsforviralparticlequantificationcurrentprogressandfutureprospects
_version_	1718409457491247104

Nanopore sensors for viral particle quantification: current progress and future prospects

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