Behavior and hippocampal Epac signaling to nicotine CPP in mice

Tobacco use is a major challenge to public health in the United States and across the world. Many studies have demonstrated that adult men and women differ in their responses to tobacco smoking, however neurobiological studies about the effect of smoking on males and females were limited. Exchange p...

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Autores principales:	Liu Jing, Tao Xinrong, Liu Fei, Hu Yuting, Xue Song, Wang Qi, Li Bing, Zhang Rongbo
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2019
Materias:	nicotine epac rap1 pcreb conditioned place preference Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/2e0f556aa964448199030cf8a70d429f
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spelling	oai:doaj.org-article:2e0f556aa964448199030cf8a70d429f2021-12-05T14:11:04ZBehavior and hippocampal Epac signaling to nicotine CPP in mice2081-693610.1515/tnsci-2019-0041https://doaj.org/article/2e0f556aa964448199030cf8a70d429f2019-10-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2019-0041https://doaj.org/toc/2081-6936Tobacco use is a major challenge to public health in the United States and across the world. Many studies have demonstrated that adult men and women differ in their responses to tobacco smoking, however neurobiological studies about the effect of smoking on males and females were limited. Exchange protein directly activated by cAMP (Epac) signaling participates in drug addictive behaviors. In this study, we examined the hippocampal Epac signaling in nicotine-induced place conditioning mice. Nicotine at 0.2 mg/kg and 0.4 mg/kg induced a conditioned place preference (CPP) in male and female mice, respectively. After CPP, male mice presented less anxiety-like behavior as demonstrated by an open-field test. The hippocampal Epac2 protein was elevated in both male and female nicotine place conditioning mice. However, Rap1 protein was elevated and CREB phosphorylation was reduced in female nicotine place conditioning mice. Our data provide direct evidence that hippocampal Epac signaling is altered in nicotine-induced CPP mice. Pharmacology manipulation Epac signaling may open a new avenue for the treatment of nicotine abuse and dependence.Liu JingTao XinrongLiu FeiHu YutingXue SongWang QiLi BingZhang RongboDe Gruyterarticlenicotineepacrap1pcrebconditioned place preferenceNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 10, Iss 1, Pp 254-259 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	nicotine epac rap1 pcreb conditioned place preference Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	nicotine epac rap1 pcreb conditioned place preference Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Liu Jing Tao Xinrong Liu Fei Hu Yuting Xue Song Wang Qi Li Bing Zhang Rongbo Behavior and hippocampal Epac signaling to nicotine CPP in mice
description	Tobacco use is a major challenge to public health in the United States and across the world. Many studies have demonstrated that adult men and women differ in their responses to tobacco smoking, however neurobiological studies about the effect of smoking on males and females were limited. Exchange protein directly activated by cAMP (Epac) signaling participates in drug addictive behaviors. In this study, we examined the hippocampal Epac signaling in nicotine-induced place conditioning mice. Nicotine at 0.2 mg/kg and 0.4 mg/kg induced a conditioned place preference (CPP) in male and female mice, respectively. After CPP, male mice presented less anxiety-like behavior as demonstrated by an open-field test. The hippocampal Epac2 protein was elevated in both male and female nicotine place conditioning mice. However, Rap1 protein was elevated and CREB phosphorylation was reduced in female nicotine place conditioning mice. Our data provide direct evidence that hippocampal Epac signaling is altered in nicotine-induced CPP mice. Pharmacology manipulation Epac signaling may open a new avenue for the treatment of nicotine abuse and dependence.
format	article
author	Liu Jing Tao Xinrong Liu Fei Hu Yuting Xue Song Wang Qi Li Bing Zhang Rongbo
author_facet	Liu Jing Tao Xinrong Liu Fei Hu Yuting Xue Song Wang Qi Li Bing Zhang Rongbo
author_sort	Liu Jing
title	Behavior and hippocampal Epac signaling to nicotine CPP in mice
title_short	Behavior and hippocampal Epac signaling to nicotine CPP in mice
title_full	Behavior and hippocampal Epac signaling to nicotine CPP in mice
title_fullStr	Behavior and hippocampal Epac signaling to nicotine CPP in mice
title_full_unstemmed	Behavior and hippocampal Epac signaling to nicotine CPP in mice
title_sort	behavior and hippocampal epac signaling to nicotine cpp in mice
publisher	De Gruyter
publishDate	2019
url	https://doaj.org/article/2e0f556aa964448199030cf8a70d429f
work_keys_str_mv	AT liujing behaviorandhippocampalepacsignalingtonicotinecppinmice AT taoxinrong behaviorandhippocampalepacsignalingtonicotinecppinmice AT liufei behaviorandhippocampalepacsignalingtonicotinecppinmice AT huyuting behaviorandhippocampalepacsignalingtonicotinecppinmice AT xuesong behaviorandhippocampalepacsignalingtonicotinecppinmice AT wangqi behaviorandhippocampalepacsignalingtonicotinecppinmice AT libing behaviorandhippocampalepacsignalingtonicotinecppinmice AT zhangrongbo behaviorandhippocampalepacsignalingtonicotinecppinmice
_version_	1718371411477659648

Behavior and hippocampal Epac signaling to nicotine CPP in mice

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