Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice

Adhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, re...

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Autores principales:	Aniruddha Adhikari, Susmita Mondal, Tanima Chatterjee, Monojit Das, Pritam Biswas, Ria Ghosh, Soumendra Darbar, Hussain Alessa, Jalal T. Althakafy, Ali Sayqal, Saleh A. Ahmed, Anjan Kumar Das, Maitree Bhattacharyya, Samir Kumar Pal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2e1b13424ead40f9aeabdec7b1deeefd
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spelling	oai:doaj.org-article:2e1b13424ead40f9aeabdec7b1deeefd2021-12-02T15:09:22ZRedox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice10.1038/s42003-021-02546-82399-3642https://doaj.org/article/2e1b13424ead40f9aeabdec7b1deeefd2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02546-8https://doaj.org/toc/2399-3642Adhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, reducing intracellular ROS, downregulating pro-inflammatory cytokines and maintaining cellular redox homeostasis.Aniruddha AdhikariSusmita MondalTanima ChatterjeeMonojit DasPritam BiswasRia GhoshSoumendra DarbarHussain AlessaJalal T. AlthakafyAli SayqalSaleh A. AhmedAnjan Kumar DasMaitree BhattacharyyaSamir Kumar PalNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Aniruddha Adhikari Susmita Mondal Tanima Chatterjee Monojit Das Pritam Biswas Ria Ghosh Soumendra Darbar Hussain Alessa Jalal T. Althakafy Ali Sayqal Saleh A. Ahmed Anjan Kumar Das Maitree Bhattacharyya Samir Kumar Pal Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
description	Adhikari et al. use the redox modulatory abilities of citrate functionalized Mn3O4 nanoparticles to ameliorate oxidative damage in murine disease model of chronic kidney disease (CKD). This nanomedicine works by protecting structural and functional integrity of mitochondria from oxidative injury, reducing intracellular ROS, downregulating pro-inflammatory cytokines and maintaining cellular redox homeostasis.
format	article
author	Aniruddha Adhikari Susmita Mondal Tanima Chatterjee Monojit Das Pritam Biswas Ria Ghosh Soumendra Darbar Hussain Alessa Jalal T. Althakafy Ali Sayqal Saleh A. Ahmed Anjan Kumar Das Maitree Bhattacharyya Samir Kumar Pal
author_facet	Aniruddha Adhikari Susmita Mondal Tanima Chatterjee Monojit Das Pritam Biswas Ria Ghosh Soumendra Darbar Hussain Alessa Jalal T. Althakafy Ali Sayqal Saleh A. Ahmed Anjan Kumar Das Maitree Bhattacharyya Samir Kumar Pal
author_sort	Aniruddha Adhikari
title	Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
title_short	Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
title_full	Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
title_fullStr	Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
title_full_unstemmed	Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice
title_sort	redox nanomedicine ameliorates chronic kidney disease (ckd) by mitochondrial reconditioning in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e1b13424ead40f9aeabdec7b1deeefd
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Redox nanomedicine ameliorates chronic kidney disease (CKD) by mitochondrial reconditioning in mice

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